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- W2044332972 abstract "A workshop on inverse agonism * Workshop on Inverse Agonism, 22–24 June 2000, Barcelona, Spain. *Workshop on Inverse Agonism, 22–24 June 2000, Barcelona, Spain. attracted over 100 participants from both academia and the pharmaceutical industry to Barcelona during June this year to discuss the subject of inverse agonism and to conclude the EU-sponsored programme ‘Inverse agonism. Implications for drug design’. In retrospect, it seems remarkable that at the inception of this programme ‘inverse agonism’ was a novel term in the pharmacological lexicon for G-protein-coupled receptors (GPCRs). However, although the programme was designed to integrate chemistry, molecular biology and systems physiology, and a key objective of the programme was to assess the physiological relevance of inverse agonism, this final issue still remains a major point of contention 1 De Ligt R.A.F. et al. Inverse agonism at G protein-coupled receptors: (patho)physiological relevance and implications for drug discovery. Br. J. Pharmacol. 2000; 130: 1-12 Crossref PubMed Scopus (178) Google Scholar . At least in part, this debate reflected the lack of appropriately controlled parallel clinical trials with both an inverse agonist and a neutral antagonist targeted at the same receptor." @default.
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- W2044332972 date "2000-10-01" @default.
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- W2044332972 title "Stochastic multidimensional hypercubes and inverse agonism" @default.
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- W2044332972 doi "https://doi.org/10.1016/s0165-6147(00)01540-6" @default.
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