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- W2044333860 abstract "The acute hypoglycemic action of intravenous insulin has been studied by a continuous 14C-glucose dilution technique in 11 insulin-dependent, nonobese, ketosisprone diabetics. Despite wide individual variation, a significant relation was found between the magnitude of the calculated suppression of hepatic glucose output (HGO) after insulin and the rate of acute blood glucose fall (KITT). No such relation was found between increased peripheral outflow and glucose fall, but both the KITT and the decrease in HGO were inversely related to the initial blood glucose. Neither KITT nor HGO suppression was dependent on insulin antibody titer, which increased with age but not duration of diabetes. It is concluded that the acute hypoglycemic effect of intravenous insulin in insulin-dependent diabetics is determined mainly by the suppression of HGO produced and that this is not related to insulin antibodies." @default.
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- W2044333860 date "1971-09-01" @default.
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- W2044333860 title "Acute hypoglycemic action of insulin in insulin-dependent diabetics" @default.
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- W2044333860 doi "https://doi.org/10.1016/0026-0495(71)90048-5" @default.
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