Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044334580> ?p ?o ?g. }
- W2044334580 endingPage "13" @default.
- W2044334580 startingPage "7" @default.
- W2044334580 abstract "Background: Pancreatic cancers often develop in the context of pancreatic fibrosis caused by chronic pancreas inflammation, which also results in the accumulation of reactive oxygen species (ROS), pancreatic parenchymal cell death, and stellate cell activation. Angiotensin II, which is converted from angiotensin I bytheangiotensin-converting enzyme (ACE), stimulates ROS production via NADPH oxidase. In stellate cells, angiotensin II activates the stress-activated protein kinase p38. However, the molecular mechanism by which angiotensin II regulates pancreatic inflammation and fibrosis remains to be determined. Methods: Wistar Bonn/Kobori (WBN/Kob) rats spontaneously develop chronic pancreatic inflammation. To examine whether blockade of the renin-angiotensin system affects the development of pancreatic fibrosis, WBN/Kob rats were given angiotensin II type 1 receptor (AT1R) blocker or ACE inhibitor (ACEI). Next, we assessed the role of angiotensin II and its possible downstream target p38α in stellate cell activation using primary stellate cells. Results: Treatment with AT1R blocker and ACEI prevented the development of chronic pancreatitis and fibrosis. In stellate cells, angiotensin II upregulated the expression of angiotensin II receptors, α-smooth muscle actin (SMA) and transforming growth factor-β. In addition, p38α was found to be essential to collagen type I production and α-SMA expression. ROS accumulation is enhanced in chronic pancreatic inflammation, which increases the risk of pancreatic cancer. Conclusions: Inhibition of the angiotensin II signaling pathway might be a promising strategy to prevent pancreatic fibrogenesis and subsequent carcinogenesis." @default.
- W2044334580 created "2016-06-24" @default.
- W2044334580 creator A5003038901 @default.
- W2044334580 creator A5005124549 @default.
- W2044334580 creator A5007382484 @default.
- W2044334580 creator A5020953323 @default.
- W2044334580 creator A5027578308 @default.
- W2044334580 creator A5032900701 @default.
- W2044334580 creator A5073197601 @default.
- W2044334580 date "2011-04-01" @default.
- W2044334580 modified "2023-10-16" @default.
- W2044334580 title "Involvement of Angiotensin II and Reactive Oxygen Species in Pancreatic Fibrosis" @default.
- W2044334580 cites W1965909642 @default.
- W2044334580 cites W1967423388 @default.
- W2044334580 cites W1970580715 @default.
- W2044334580 cites W1971092302 @default.
- W2044334580 cites W1987291131 @default.
- W2044334580 cites W1992481999 @default.
- W2044334580 cites W1994733930 @default.
- W2044334580 cites W2025457472 @default.
- W2044334580 cites W2027954852 @default.
- W2044334580 cites W2033800625 @default.
- W2044334580 cites W2036349665 @default.
- W2044334580 cites W2048677607 @default.
- W2044334580 cites W2056565204 @default.
- W2044334580 cites W2062289724 @default.
- W2044334580 cites W2064918098 @default.
- W2044334580 cites W2083648000 @default.
- W2044334580 cites W2090709209 @default.
- W2044334580 cites W2097995983 @default.
- W2044334580 cites W2099021742 @default.
- W2044334580 cites W2109024264 @default.
- W2044334580 cites W2115898270 @default.
- W2044334580 cites W2118287470 @default.
- W2044334580 cites W2135298606 @default.
- W2044334580 cites W2139139966 @default.
- W2044334580 cites W2148929898 @default.
- W2044334580 cites W2150278759 @default.
- W2044334580 cites W2159786644 @default.
- W2044334580 cites W2318156113 @default.
- W2044334580 cites W2324431763 @default.
- W2044334580 cites W2614442853 @default.
- W2044334580 cites W4255712601 @default.
- W2044334580 doi "https://doi.org/10.1159/000323478" @default.
- W2044334580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21464581" @default.
- W2044334580 hasPublicationYear "2011" @default.
- W2044334580 type Work @default.
- W2044334580 sameAs 2044334580 @default.
- W2044334580 citedByCount "31" @default.
- W2044334580 countsByYear W20443345802012 @default.
- W2044334580 countsByYear W20443345802013 @default.
- W2044334580 countsByYear W20443345802014 @default.
- W2044334580 countsByYear W20443345802016 @default.
- W2044334580 countsByYear W20443345802017 @default.
- W2044334580 countsByYear W20443345802018 @default.
- W2044334580 countsByYear W20443345802019 @default.
- W2044334580 countsByYear W20443345802020 @default.
- W2044334580 countsByYear W20443345802021 @default.
- W2044334580 countsByYear W20443345802022 @default.
- W2044334580 crossrefType "journal-article" @default.
- W2044334580 hasAuthorship W2044334580A5003038901 @default.
- W2044334580 hasAuthorship W2044334580A5005124549 @default.
- W2044334580 hasAuthorship W2044334580A5007382484 @default.
- W2044334580 hasAuthorship W2044334580A5020953323 @default.
- W2044334580 hasAuthorship W2044334580A5027578308 @default.
- W2044334580 hasAuthorship W2044334580A5032900701 @default.
- W2044334580 hasAuthorship W2044334580A5073197601 @default.
- W2044334580 hasConcept C104849204 @default.
- W2044334580 hasConcept C126322002 @default.
- W2044334580 hasConcept C134018914 @default.
- W2044334580 hasConcept C170493617 @default.
- W2044334580 hasConcept C176891718 @default.
- W2044334580 hasConcept C198710026 @default.
- W2044334580 hasConcept C27016395 @default.
- W2044334580 hasConcept C2775967933 @default.
- W2044334580 hasConcept C2776737053 @default.
- W2044334580 hasConcept C2776914184 @default.
- W2044334580 hasConcept C2778764654 @default.
- W2044334580 hasConcept C2780559512 @default.
- W2044334580 hasConcept C2908929049 @default.
- W2044334580 hasConcept C48349386 @default.
- W2044334580 hasConcept C502942594 @default.
- W2044334580 hasConcept C71924100 @default.
- W2044334580 hasConcept C84393581 @default.
- W2044334580 hasConcept C86803240 @default.
- W2044334580 hasConcept C95444343 @default.
- W2044334580 hasConceptScore W2044334580C104849204 @default.
- W2044334580 hasConceptScore W2044334580C126322002 @default.
- W2044334580 hasConceptScore W2044334580C134018914 @default.
- W2044334580 hasConceptScore W2044334580C170493617 @default.
- W2044334580 hasConceptScore W2044334580C176891718 @default.
- W2044334580 hasConceptScore W2044334580C198710026 @default.
- W2044334580 hasConceptScore W2044334580C27016395 @default.
- W2044334580 hasConceptScore W2044334580C2775967933 @default.
- W2044334580 hasConceptScore W2044334580C2776737053 @default.
- W2044334580 hasConceptScore W2044334580C2776914184 @default.
- W2044334580 hasConceptScore W2044334580C2778764654 @default.
- W2044334580 hasConceptScore W2044334580C2780559512 @default.