FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044335055> ?p ?o ?g. }

• W2044335055 abstract "Phenotypically, ganciclovir-resistant human cytomegalovirus strains could be selected by aciclovir as effectively as by ganciclovir in vitro. Three clinical human cytomegalovirus isolates with different sensitivities against ganciclovir, aciclovir, foscarnet, and cidofovir, but without any mutation in the viral UL97 protein known to confer ganciclovir resistance, were propagated each in duplicate in the presence of ganciclovir or aciclovir. After drug selection, all 12 strains were less susceptible to ganciclovir (increase of 50% focus reduction dose between 2.1- and 31.5-fold) but were still sensitive to foscarnet and cidofovir; 7/12 exhibited a ganciclovir-resistant phenotype with a 50% focus reduction dose >30 microM, and in 6 out of these typical mutations in the UL97 coding region could be found by genotyping. All four strains selected from one isolate carried the identical UL97 mutation at amino acid position 460 (methionine to valine). The decreased sensitivity to ganciclovir and aciclovir in the other strains could neither be attributed to known UL97 mutations nor to mutations in the viral polymerase (UL54), which have been reported to induce resistance." @default.
• W2044335055 created "2016-06-24" @default.
• W2044335055 creator A5001007179 @default.
• W2044335055 creator A5003242378 @default.
• W2044335055 creator A5029950470 @default.
• W2044335055 creator A5057322077 @default.
• W2044335055 creator A5082627204 @default.
• W2044335055 date "2001-07-31" @default.
• W2044335055 modified "2023-09-24" @default.
• W2044335055 title "Aciclovir selects for ganciclovir-cross-resistance of human cytomegalovirus in vitro that is only in part explained by known mutations in the UL97 protein*" @default.
• W2044335055 cites W1534449947 @default.
• W2044335055 cites W1689344910 @default.
• W2044335055 cites W1826074163 @default.
• W2044335055 cites W1974317867 @default.
• W2044335055 cites W1975613076 @default.
• W2044335055 cites W1976379944 @default.
• W2044335055 cites W2011706129 @default.
• W2044335055 cites W2015275952 @default.
• W2044335055 cites W2015772291 @default.
• W2044335055 cites W2036402660 @default.
• W2044335055 cites W2036876068 @default.
• W2044335055 cites W2061391965 @default.
• W2044335055 cites W2071003885 @default.
• W2044335055 cites W2071192015 @default.
• W2044335055 cites W2091704657 @default.
• W2044335055 cites W2105057089 @default.
• W2044335055 cites W2126082952 @default.
• W2044335055 cites W2138115368 @default.
• W2044335055 cites W2146252421 @default.
• W2044335055 cites W2161156906 @default.
• W2044335055 cites W2167351117 @default.
• W2044335055 cites W2168528200 @default.
• W2044335055 cites W2169878631 @default.
• W2044335055 cites W2317836667 @default.
• W2044335055 cites W4242511899 @default.
• W2044335055 doi "https://doi.org/10.1002/jmv.2003" @default.
• W2044335055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11505446" @default.
• W2044335055 hasPublicationYear "2001" @default.
• W2044335055 type Work @default.
• W2044335055 sameAs 2044335055 @default.
• W2044335055 citedByCount "34" @default.
• W2044335055 countsByYear W20443350552012 @default.
• W2044335055 countsByYear W20443350552013 @default.
• W2044335055 countsByYear W20443350552016 @default.
• W2044335055 countsByYear W20443350552018 @default.
• W2044335055 countsByYear W20443350552019 @default.
• W2044335055 crossrefType "journal-article" @default.
• W2044335055 hasAuthorship W2044335055A5001007179 @default.
• W2044335055 hasAuthorship W2044335055A5003242378 @default.
• W2044335055 hasAuthorship W2044335055A5029950470 @default.
• W2044335055 hasAuthorship W2044335055A5057322077 @default.
• W2044335055 hasAuthorship W2044335055A5082627204 @default.
• W2044335055 hasConcept C159047783 @default.
• W2044335055 hasConcept C2522874641 @default.
• W2044335055 hasConcept C2776317777 @default.
• W2044335055 hasConcept C2776409557 @default.
• W2044335055 hasConcept C2776724271 @default.
• W2044335055 hasConcept C2776824251 @default.
• W2044335055 hasConcept C2777965375 @default.
• W2044335055 hasConcept C2779450786 @default.
• W2044335055 hasConcept C2779820661 @default.
• W2044335055 hasConcept C2780727368 @default.
• W2044335055 hasConcept C86803240 @default.
• W2044335055 hasConceptScore W2044335055C159047783 @default.
• W2044335055 hasConceptScore W2044335055C2522874641 @default.
• W2044335055 hasConceptScore W2044335055C2776317777 @default.
• W2044335055 hasConceptScore W2044335055C2776409557 @default.
• W2044335055 hasConceptScore W2044335055C2776724271 @default.
• W2044335055 hasConceptScore W2044335055C2776824251 @default.
• W2044335055 hasConceptScore W2044335055C2777965375 @default.
• W2044335055 hasConceptScore W2044335055C2779450786 @default.
• W2044335055 hasConceptScore W2044335055C2779820661 @default.
• W2044335055 hasConceptScore W2044335055C2780727368 @default.
• W2044335055 hasConceptScore W2044335055C86803240 @default.
• W2044335055 hasLocation W20443350551 @default.
• W2044335055 hasLocation W20443350552 @default.
• W2044335055 hasOpenAccess W2044335055 @default.
• W2044335055 hasPrimaryLocation W20443350551 @default.
• W2044335055 hasRelatedWork W1593537817 @default.
• W2044335055 hasRelatedWork W1689344910 @default.
• W2044335055 hasRelatedWork W1976379944 @default.
• W2044335055 hasRelatedWork W1981131063 @default.
• W2044335055 hasRelatedWork W1996817385 @default.
• W2044335055 hasRelatedWork W2021690030 @default.
• W2044335055 hasRelatedWork W2026049852 @default.
• W2044335055 hasRelatedWork W2036876068 @default.
• W2044335055 hasRelatedWork W2055531146 @default.
• W2044335055 hasRelatedWork W2060620691 @default.
• W2044335055 hasRelatedWork W2071003885 @default.
• W2044335055 hasRelatedWork W2071192015 @default.
• W2044335055 hasRelatedWork W2094391390 @default.
• W2044335055 hasRelatedWork W2104237063 @default.
• W2044335055 hasRelatedWork W2114786252 @default.
• W2044335055 hasRelatedWork W2124758522 @default.
• W2044335055 hasRelatedWork W2129127406 @default.
• W2044335055 hasRelatedWork W2133511703 @default.
• W2044335055 hasRelatedWork W2161156906 @default.
• W2044335055 hasRelatedWork W2168046861 @default.
• W2044335055 isParatext "false" @default.
• W2044335055 isRetracted "false" @default.

• next