Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044335916> ?p ?o ?g. }
- W2044335916 abstract "Abstract The development of RNA interference (RNAi)-based therapy faces two major obstacles: selecting small interfering RNA (siRNA) sequences with strong activity and identifying a carrier that allows efficient delivery to target organs. Additionally, conservative region at nucleotide level must be targeted for RNAi in applying to virus because hepatitis C virus (HCV) could escape from therapeutic pressure with genome mutations. In vitro preparation of Dicer-generated siRNAs targeting a conserved, highly ordered HCV 5′ untranslated region are capable of inducing strong RNAi activity. By dissecting the 5′-end of an RNAi-mediated cleavage site in the HCV genome, we identified potent siRNA sequences, which we designate as Dicer-hunting siRNAs (dh-siRNAs). Furthermore, formulation of the dh-siRNAs in an optimized multifunctional envelope-type nano device inhibited ongoing infectious HCV replication in human hepatocytes in vivo . Our efforts using both identification of optimal siRNA sequences and delivery to human hepatocytes suggest therapeutic potential of siRNA for a virus." @default.
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- W2044335916 date "2014-04-23" @default.
- W2044335916 modified "2023-09-28" @default.
- W2044335916 title "In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus." @default.
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- W2044335916 doi "https://doi.org/10.1038/srep04750" @default.
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