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- W2044335923 abstract "Newborn infants (NB) with cyanotic heart disease and reduced pulmonary flow are often ductus-dependent and improve with prostaglandin (PGE) infusion. However, PGE may fail if the ductus arteriosus is absent. The angiograms of 19 cyanotic NB (mean age 2.7 d) were analyzed. Group A consisted of 5 with ADA, and group B of 14 with patent ductus (PDA). All had pulmonary atresia complex with or without VSD. The diameters of aorta (ascending [AA], descending [DA], at diaphragm level [DDA]), right pulmonary artery (RPA), and left pulmonary artery (LPA) were obtained. Aortic size in A did not differ from those in B at all 3 levels. However, RPA and LPA were smaller in A than in B shown by mean pulmonary/aortic ratios: RPA/AA = 0.21 vs 0.389, RPA/DA = 0.38 vs 0.628, RPA/DDA = 0.41 v 0.64, LPA/AA = 0.20 vs 0.36, LPA/DA = 0.36 vs 0.60, LPA/DDA = 0.39 vs 0.605 (p value in all < 0.005), indicating impaired pulmonary artery growth in utero in pulmonary atresia or severe pulmonary stenosis with ADA. The angiograms in B showed PDA in all, and no increase of bronchial collaterals. In contrast, bronchial flow was abundant in A. Aortic valve stenosis was present in 3/5 in A but in 0/14 in B. ADA may be suspected clinically in cyanotic NB with reduced pulmonary flow if there is no response to PGE infusion and/or if aortic valve stenosis is also present. The diagnosis may be established angiographically based on non-visualization of the ductus, diminutive pulmonary arteries and abundant bronchial flow." @default.
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- W2044335923 date "1981-04-01" @default.
- W2044335923 modified "2023-09-25" @default.
- W2044335923 title "1349 CONGENITAL ABSENCE OF DUCTUS ARTERIOSUS (ADA)" @default.
- W2044335923 doi "https://doi.org/10.1203/00006450-198104001-01378" @default.
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