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- W2044335931 abstract "Efficient syntheses of a series of functionalized aryl enediynes have been developed. The building blocks were used to effect conjugation to carrier PEG templates which allowed subsequent coupling to a cardiac targeted monoclonal antibody. Immunocompetence of the enediyne-Mab conjugates was demonstrated by ELISA, and both parent enediynes and bioconjugates underwent successful photo-Bergman cyclization. Finally, surface modified (Au) nanoparticle conjugates were prepared and size confirmed by TEM analysis. Application as long-circulating photoactivated prodrugs is anticipated." @default.
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- W2044335931 date "2008-02-01" @default.
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- W2044335931 title "Photoactivated enediynes as targeted antitumoral agents: Efficient routes to antibody and gold nanoparticle conjugates" @default.
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- W2044335931 doi "https://doi.org/10.1016/j.bmcl.2007.12.045" @default.
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