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• W2044339965 abstract "Functional and morphologic observations are reported in six patients who developed graft versus host reactions following transplantation of allogeneic thymic, blood, or bone marrow cells. Five had severe dual system immunodeficiency diseases and the sixth had Hodgkin's disease. Each developed a characteristic skin rash and characteristic histopathologic abnormalities of the skin; the severity of the reaction was most often interpretable in terms of the degree of histocompatibility difference between donor and recipient. Milder and even long lasting chronic graft versus host reactions were observed when donor and recipient were matched according to the major HL-A determinants. Gastrointestinal manifestations were especially serious and sometimes fatal complications; the severity appeared often to be related to the use of cytotoxic drugs. Morphologic evidence of the graft versus host reaction was observed in the thymus of one patient who was given putative stem cells from a mismatched donor. The theoretical implications and restrictions imposed by this observation are considered in relation to future attempts at reconstitution of immunologically deficient patients." @default.
• W2044339965 created "2016-06-24" @default.
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• W2044339965 date "1971-09-01" @default.
• W2044339965 modified "2023-10-02" @default.
• W2044339965 title "Graft versus host reactions following transplantation of allogeneic hematopoietic cells" @default.
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• W2044339965 doi "https://doi.org/10.1016/s0046-8177(71)80006-0" @default.
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