Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044348032> ?p ?o ?g. }
- W2044348032 endingPage "2552" @default.
- W2044348032 startingPage "2537" @default.
- W2044348032 abstract "During a global research expedition, more than five hundred marine bacterial strains capable of inhibiting the growth of pathogenic bacteria were collected. The purpose of the present study was to determine if these marine bacteria are also a source of compounds that interfere with the agr quorum sensing system that controls virulence gene expression in Staphylococcus aureus. Using a gene reporter fusion bioassay, we recorded agr interference as enhanced expression of spa, encoding Protein A, concomitantly with reduced expression of hla, encoding α-hemolysin, and rnaIII encoding RNAIII, the effector molecule of agr. A marine Photobacterium produced compounds interfering with agr in S. aureus strain 8325-4, and bioassay-guided fractionation of crude extracts led to the isolation of two novel cyclodepsipeptides, designated solonamide A and B. Northern blot analysis confirmed the agr interfering activity of pure solonamides in both S. aureus strain 8325-4 and the highly virulent, community-acquired strain USA300 (CA-MRSA). To our knowledge, this is the first report of inhibitors of the agr system by a marine bacterium." @default.
- W2044348032 created "2016-06-24" @default.
- W2044348032 creator A5005938912 @default.
- W2044348032 creator A5028557780 @default.
- W2044348032 creator A5029490663 @default.
- W2044348032 creator A5047092331 @default.
- W2044348032 creator A5061787967 @default.
- W2044348032 creator A5061953998 @default.
- W2044348032 creator A5071053620 @default.
- W2044348032 creator A5073559586 @default.
- W2044348032 date "2011-12-07" @default.
- W2044348032 modified "2023-09-30" @default.
- W2044348032 title "Inhibition of Virulence Gene Expression in Staphylococcus aureus by Novel Depsipeptides from a Marine Photobacterium" @default.
- W2044348032 cites W1489237778 @default.
- W2044348032 cites W1508220546 @default.
- W2044348032 cites W1553185642 @default.
- W2044348032 cites W1562957659 @default.
- W2044348032 cites W18542036 @default.
- W2044348032 cites W1966626297 @default.
- W2044348032 cites W1971909479 @default.
- W2044348032 cites W1971981678 @default.
- W2044348032 cites W1976113023 @default.
- W2044348032 cites W1980601483 @default.
- W2044348032 cites W1986503675 @default.
- W2044348032 cites W1987400078 @default.
- W2044348032 cites W1991125394 @default.
- W2044348032 cites W1994462493 @default.
- W2044348032 cites W1994895410 @default.
- W2044348032 cites W1997168629 @default.
- W2044348032 cites W2002946611 @default.
- W2044348032 cites W2003906118 @default.
- W2044348032 cites W2003940898 @default.
- W2044348032 cites W2005077472 @default.
- W2044348032 cites W2005636153 @default.
- W2044348032 cites W2008679353 @default.
- W2044348032 cites W2009156161 @default.
- W2044348032 cites W2016935145 @default.
- W2044348032 cites W2018917527 @default.
- W2044348032 cites W2022321105 @default.
- W2044348032 cites W2024341634 @default.
- W2044348032 cites W2025297513 @default.
- W2044348032 cites W2030229682 @default.
- W2044348032 cites W2031236008 @default.
- W2044348032 cites W2031284066 @default.
- W2044348032 cites W2041058741 @default.
- W2044348032 cites W2041553283 @default.
- W2044348032 cites W2043792155 @default.
- W2044348032 cites W2043966259 @default.
- W2044348032 cites W2044878310 @default.
- W2044348032 cites W2045961932 @default.
- W2044348032 cites W2058571049 @default.
- W2044348032 cites W2060816398 @default.
- W2044348032 cites W2066077786 @default.
- W2044348032 cites W2071123327 @default.
- W2044348032 cites W2071318114 @default.
- W2044348032 cites W2073233593 @default.
- W2044348032 cites W2082789913 @default.
- W2044348032 cites W2085360512 @default.
- W2044348032 cites W2087726825 @default.
- W2044348032 cites W2088970163 @default.
- W2044348032 cites W2089535298 @default.
- W2044348032 cites W2095830310 @default.
- W2044348032 cites W2100195325 @default.
- W2044348032 cites W2101613981 @default.
- W2044348032 cites W2107804628 @default.
- W2044348032 cites W2110355774 @default.
- W2044348032 cites W2113068809 @default.
- W2044348032 cites W2113885410 @default.
- W2044348032 cites W2113961626 @default.
- W2044348032 cites W2115127793 @default.
- W2044348032 cites W2115771487 @default.
- W2044348032 cites W2116771891 @default.
- W2044348032 cites W2119010870 @default.
- W2044348032 cites W2122020611 @default.
- W2044348032 cites W2131230616 @default.
- W2044348032 cites W2135056208 @default.
- W2044348032 cites W2139426406 @default.
- W2044348032 cites W2139697588 @default.
- W2044348032 cites W2143785612 @default.
- W2044348032 cites W2150610836 @default.
- W2044348032 cites W2155297808 @default.
- W2044348032 cites W2155864378 @default.
- W2044348032 cites W2159224038 @default.
- W2044348032 cites W2167450753 @default.
- W2044348032 cites W2171629640 @default.
- W2044348032 cites W2177776848 @default.
- W2044348032 cites W2407967642 @default.
- W2044348032 cites W2949178661 @default.
- W2044348032 cites W4241373663 @default.
- W2044348032 doi "https://doi.org/10.3390/md9122537" @default.
- W2044348032 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3280567" @default.
- W2044348032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22363239" @default.
- W2044348032 hasPublicationYear "2011" @default.
- W2044348032 type Work @default.
- W2044348032 sameAs 2044348032 @default.
- W2044348032 citedByCount "103" @default.
- W2044348032 countsByYear W20443480322012 @default.
- W2044348032 countsByYear W20443480322013 @default.