FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044348303> ?p ?o ?g. }

• W2044348303 endingPage "97" @default.
• W2044348303 startingPage "91" @default.
• W2044348303 abstract "Background: Green tea has been shown to improve cholesterol metabolism in animal studies, but the molecular mechanisms underlying this function have not been fully understood. Long non-coding RNAs (lncRNAs) have recently emerged as a major class of regulatory molecules involved in a broad range of biological processes and complex diseases. Our aim was to identify important lncRNAs that might play an important role in contributing to the benefits of epigallocatechin-3-gallate (EGCG) on cholesterol metabolism. Methods: Microarrays was used to reveal the lncRNA and mRNA profiles in green tea polyphenol(-)-epigallocatechin gallate in cultured human liver (HepG2) hepatocytes treated with EGCG and bioinformatic analyses of the predicted target genes were performed to identify lncRNA-mRNA targeting relationships. RNA interference was used to investigate the role of lncRNAs in cholesterol metabolism. Results: The expression levels of 15 genes related to cholesterol metabolism and 285 lncRNAs were changed by EGCG treatment. Bioinformatic analysis found five matched lncRNA-mRNA pairs for five differentially expressed lncRNAs and four differentially expressed mRNA. In particular, the lncRNA AT102202 and its potential targets mRNA-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) were identified. Using a real-time polymerase chain reaction technique, we confirmed that EGCG down-regulated mRNA expression level of the HMGCR and up-regulated expression of AT102202. After AT102202 knockdown in HepG2, we observed that the level of HMGCR expression was significantly increased relative to the scrambled small interfering RNA control (P < 0.05). Conclusions: Our results indicated that EGCG improved cholesterol metabolism and meanwhile changed the lncRNAs expression profile in HepG2 cells. LncRNAs may play an important role in the cholesterol metabolism." @default.
• W2044348303 created "2016-06-24" @default.
• W2044348303 creator A5009869937 @default.
• W2044348303 creator A5014793812 @default.
• W2044348303 creator A5051645715 @default.
• W2044348303 creator A5057957690 @default.
• W2044348303 creator A5058637832 @default.
• W2044348303 creator A5090210069 @default.
• W2044348303 date "2015-01-01" @default.
• W2044348303 modified "2023-09-30" @default.
• W2044348303 title "Long Non-coding RNAs Expression Profile in HepG2 Cells Reveals the Potential Role of Long Non-coding RNAs in the Cholesterol Metabolism" @default.
• W2044348303 cites W1967114053 @default.
• W2044348303 cites W1970516435 @default.
• W2044348303 cites W1975760076 @default.
• W2044348303 cites W1975909559 @default.
• W2044348303 cites W1977083917 @default.
• W2044348303 cites W1977751039 @default.
• W2044348303 cites W1978485989 @default.
• W2044348303 cites W1985582643 @default.
• W2044348303 cites W1999746344 @default.
• W2044348303 cites W2020585666 @default.
• W2044348303 cites W2020988004 @default.
• W2044348303 cites W2022864291 @default.
• W2044348303 cites W2033094967 @default.
• W2044348303 cites W2041826111 @default.
• W2044348303 cites W2042421971 @default.
• W2044348303 cites W2069104338 @default.
• W2044348303 cites W2069327089 @default.
• W2044348303 cites W2070785261 @default.
• W2044348303 cites W2072033965 @default.
• W2044348303 cites W2084087850 @default.
• W2044348303 cites W2088017477 @default.
• W2044348303 cites W2091161969 @default.
• W2044348303 cites W2100982253 @default.
• W2044348303 cites W2104215271 @default.
• W2044348303 cites W2107460318 @default.
• W2044348303 cites W2127933204 @default.
• W2044348303 cites W2129110965 @default.
• W2044348303 cites W2131444897 @default.
• W2044348303 cites W2146573461 @default.
• W2044348303 cites W2157512257 @default.
• W2044348303 cites W2161159766 @default.
• W2044348303 cites W2169247555 @default.
• W2044348303 cites W2176555004 @default.
• W2044348303 cites W4211191293 @default.
• W2044348303 cites W4292172722 @default.
• W2044348303 doi "https://doi.org/10.4103/0366-6999.147824" @default.
• W2044348303 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4837827" @default.
• W2044348303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25563320" @default.
• W2044348303 hasPublicationYear "2015" @default.
• W2044348303 type Work @default.
• W2044348303 sameAs 2044348303 @default.
• W2044348303 citedByCount "48" @default.
• W2044348303 countsByYear W20443483032015 @default.
• W2044348303 countsByYear W20443483032016 @default.
• W2044348303 countsByYear W20443483032017 @default.
• W2044348303 countsByYear W20443483032018 @default.
• W2044348303 countsByYear W20443483032019 @default.
• W2044348303 countsByYear W20443483032020 @default.
• W2044348303 countsByYear W20443483032021 @default.
• W2044348303 countsByYear W20443483032022 @default.
• W2044348303 countsByYear W20443483032023 @default.
• W2044348303 crossrefType "journal-article" @default.
• W2044348303 hasAuthorship W2044348303A5009869937 @default.
• W2044348303 hasAuthorship W2044348303A5014793812 @default.
• W2044348303 hasAuthorship W2044348303A5051645715 @default.
• W2044348303 hasAuthorship W2044348303A5057957690 @default.
• W2044348303 hasAuthorship W2044348303A5058637832 @default.
• W2044348303 hasAuthorship W2044348303A5090210069 @default.
• W2044348303 hasBestOaLocation W20443483031 @default.
• W2044348303 hasConcept C104317684 @default.
• W2044348303 hasConcept C105580179 @default.
• W2044348303 hasConcept C145059251 @default.
• W2044348303 hasConcept C150194340 @default.
• W2044348303 hasConcept C166703698 @default.
• W2044348303 hasConcept C173396325 @default.
• W2044348303 hasConcept C4733338 @default.
• W2044348303 hasConcept C55493867 @default.
• W2044348303 hasConcept C62203573 @default.
• W2044348303 hasConcept C67705224 @default.
• W2044348303 hasConcept C86803240 @default.
• W2044348303 hasConcept C95371953 @default.
• W2044348303 hasConcept C95444343 @default.
• W2044348303 hasConceptScore W2044348303C104317684 @default.
• W2044348303 hasConceptScore W2044348303C105580179 @default.
• W2044348303 hasConceptScore W2044348303C145059251 @default.
• W2044348303 hasConceptScore W2044348303C150194340 @default.
• W2044348303 hasConceptScore W2044348303C166703698 @default.
• W2044348303 hasConceptScore W2044348303C173396325 @default.
• W2044348303 hasConceptScore W2044348303C4733338 @default.
• W2044348303 hasConceptScore W2044348303C55493867 @default.
• W2044348303 hasConceptScore W2044348303C62203573 @default.
• W2044348303 hasConceptScore W2044348303C67705224 @default.
• W2044348303 hasConceptScore W2044348303C86803240 @default.
• W2044348303 hasConceptScore W2044348303C95371953 @default.
• W2044348303 hasConceptScore W2044348303C95444343 @default.
• W2044348303 hasIssue "1" @default.
• W2044348303 hasLocation W20443483031 @default.

• next