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- W2044350615 abstract "The tropomyosin-related kinase (Trk) family of neurotrophin receptors, TrkA, TrkB and TrkC, has been implicated in the growth and survival of human cancers. Here we report that Trks are frequently overexpressed in hepatocellular carcinoma (HCC) from patients and human liver cancer cell lines. To unravel the underlying molecular mechanism(s) for this phenomenon, DNA methylation patterns of CpG islands in TrkA, TrkB, and TrkC genes were examined in normal and cancer cell lines derived from liver. A good correlation was observed between promoter hypermethylation and lower expression of TrkA, TrkB, and TrkC genes, which was supported by the data that inhibiting DNA methylation with 5-azacytidine restored expression of those genes in normal liver cell lines. Furthermore, Trks promoted the proliferation of HepG2 and induced expression of the metastatic regulator, Twist. These results suggest that Trks may contribute to growth and metastasis of liver cancer." @default.
- W2044350615 created "2016-06-24" @default.
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- W2044350615 date "2011-03-01" @default.
- W2044350615 modified "2023-10-07" @default.
- W2044350615 title "DNA methylation-dependent regulation of TrkA, TrkB, and TrkC genes in human hepatocellular carcinoma" @default.
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- W2044350615 doi "https://doi.org/10.1016/j.bbrc.2011.01.116" @default.
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