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- W2044355265 abstract "Abstract Chronic kidney disease is a major health problem and the global guidelines require screening of albuminuria. Therefore, affordable and sensitive albuminuria screening tests are needed. We explored the potential of urine strips, generally reported in the ordinal scale, measured on an automatic strip reader for reporting quantitative and sensitive albumin results. We compared reflectance data of Combur-Test Imprecision of the reflectance signal of the Cobas U411 was measured with commercial control material (Bio-Rad). Inter-run coefficients of variations (CVs) for reflectance for levels 1 and 2 were 1.7%/4.9%, respectively, and intra-run CVs were 1.8%/4.2%, respectively. Good agreement was obtained between the albumin concentration of the BNII and the protein strip reflectance data (n=389): Y (10000/protein reflectance, 1/%)=160+0.132·X (albuminuria BNII, mg/L)–0.0000111·X The present study demonstrates that reflectance data generated by a test strip reader allows for quantitative analysis of albumin. Although the lower limit of the microalbumin range (30 mg/L) cannot be achieved with the dye-binding method, the results are satisfactory for screening purposes." @default.
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- W2044355265 date "2012-01-01" @default.
- W2044355265 modified "2023-10-16" @default.
- W2044355265 title "A sensitive quantitative test strip based point-of-care albuminuria screening assay" @default.
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- W2044355265 doi "https://doi.org/10.1515/cclm.2012.0849" @default.
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