FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044366106> ?p ?o ?g. }

• W2044366106 endingPage "12" @default.
• W2044366106 startingPage "7" @default.
• W2044366106 abstract "The cellular response to DNA damage involves checkpoint controls that delay cell cycle progression in order to provide time for repair of damaged DNA. Chk2/hCds1 is a recently identified homolog of the yeast Cds1 kinase that is involved in cell cycle checkpoint response to DNA damage. To investigate the functions of Chk2/hCds1 in response to DNA damage in mammalian cells, we established a stable human kidney embryonic cell line (HEK‐293) that expresses antisense Chk2/hCds1 (Chk2AS) under the control of an inducible promoter. Cells that express Chk2AS display defective S‐phase delay in response to DNA replication‐mediated DNA damage induced by the topoisomerase I inhibitor camptothecin. The defective G2 checkpoint was also observed in Chk2AS cells exposed to the DNA damaging agent VP‐16 or γ‐radiation. Enhanced apoptosis was observed in Chk2AS cells after exposure to γ‐radiation or camptothecin. No p53 activation was observed after DNA damage in HEK‐293 or Chk2AS cells. Our results indicate that perturbation of Chk2/hCds1 expression adversely affects the S‐ and G2‐phase checkpoints following DNA damage or DNA replication block, and suggest that reduced expression of Chk2/hCds1 might promote a p53‐independent apoptotic response." @default.
• W2044366106 created "2016-06-24" @default.
• W2044366106 creator A5032617409 @default.
• W2044366106 creator A5042114293 @default.
• W2044366106 creator A5074513414 @default.
• W2044366106 creator A5075987263 @default.
• W2044366106 date "2001-09-06" @default.
• W2044366106 modified "2023-10-17" @default.
• W2044366106 title "Antisense inhibition of Chk2/hCds1 expression attenuates DNA damage‐induced S and G2 checkpoints and enhances apoptotic activity in HEK‐293 cells" @default.
• W2044366106 cites W1480741751 @default.
• W2044366106 cites W1677118171 @default.
• W2044366106 cites W1971775560 @default.
• W2044366106 cites W1975505901 @default.
• W2044366106 cites W1988876917 @default.
• W2044366106 cites W2012053348 @default.
• W2044366106 cites W2014722055 @default.
• W2044366106 cites W2028044172 @default.
• W2044366106 cites W2033950216 @default.
• W2044366106 cites W2043042726 @default.
• W2044366106 cites W2043136696 @default.
• W2044366106 cites W2049508647 @default.
• W2044366106 cites W2061497413 @default.
• W2044366106 cites W2097173890 @default.
• W2044366106 cites W2105768236 @default.
• W2044366106 cites W2108003526 @default.
• W2044366106 cites W2110740129 @default.
• W2044366106 cites W2112415266 @default.
• W2044366106 cites W2120921507 @default.
• W2044366106 cites W2123273708 @default.
• W2044366106 cites W2123623018 @default.
• W2044366106 cites W2128994729 @default.
• W2044366106 cites W2131833681 @default.
• W2044366106 cites W2154141161 @default.
• W2044366106 cites W2158699530 @default.
• W2044366106 cites W2159040452 @default.
• W2044366106 cites W2166548889 @default.
• W2044366106 doi "https://doi.org/10.1016/s0014-5793(01)02756-9" @default.
• W2044366106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11557032" @default.
• W2044366106 hasPublicationYear "2001" @default.
• W2044366106 type Work @default.
• W2044366106 sameAs 2044366106 @default.
• W2044366106 citedByCount "70" @default.
• W2044366106 countsByYear W20443661062012 @default.
• W2044366106 countsByYear W20443661062013 @default.
• W2044366106 countsByYear W20443661062014 @default.
• W2044366106 countsByYear W20443661062015 @default.
• W2044366106 countsByYear W20443661062017 @default.
• W2044366106 countsByYear W20443661062018 @default.
• W2044366106 countsByYear W20443661062020 @default.
• W2044366106 countsByYear W20443661062022 @default.
• W2044366106 crossrefType "journal-article" @default.
• W2044366106 hasAuthorship W2044366106A5032617409 @default.
• W2044366106 hasAuthorship W2044366106A5042114293 @default.
• W2044366106 hasAuthorship W2044366106A5074513414 @default.
• W2044366106 hasAuthorship W2044366106A5075987263 @default.
• W2044366106 hasBestOaLocation W20443661061 @default.
• W2044366106 hasConcept C105696609 @default.
• W2044366106 hasConcept C134935766 @default.
• W2044366106 hasConcept C143425029 @default.
• W2044366106 hasConcept C153911025 @default.
• W2044366106 hasConcept C174510640 @default.
• W2044366106 hasConcept C190283241 @default.
• W2044366106 hasConcept C2779682216 @default.
• W2044366106 hasConcept C2910325170 @default.
• W2044366106 hasConcept C29537977 @default.
• W2044366106 hasConcept C50001416 @default.
• W2044366106 hasConcept C54086632 @default.
• W2044366106 hasConcept C54355233 @default.
• W2044366106 hasConcept C552990157 @default.
• W2044366106 hasConcept C55493867 @default.
• W2044366106 hasConcept C73573662 @default.
• W2044366106 hasConcept C81885089 @default.
• W2044366106 hasConcept C86803240 @default.
• W2044366106 hasConcept C95444343 @default.
• W2044366106 hasConceptScore W2044366106C105696609 @default.
• W2044366106 hasConceptScore W2044366106C134935766 @default.
• W2044366106 hasConceptScore W2044366106C143425029 @default.
• W2044366106 hasConceptScore W2044366106C153911025 @default.
• W2044366106 hasConceptScore W2044366106C174510640 @default.
• W2044366106 hasConceptScore W2044366106C190283241 @default.
• W2044366106 hasConceptScore W2044366106C2779682216 @default.
• W2044366106 hasConceptScore W2044366106C2910325170 @default.
• W2044366106 hasConceptScore W2044366106C29537977 @default.
• W2044366106 hasConceptScore W2044366106C50001416 @default.
• W2044366106 hasConceptScore W2044366106C54086632 @default.
• W2044366106 hasConceptScore W2044366106C54355233 @default.
• W2044366106 hasConceptScore W2044366106C552990157 @default.
• W2044366106 hasConceptScore W2044366106C55493867 @default.
• W2044366106 hasConceptScore W2044366106C73573662 @default.
• W2044366106 hasConceptScore W2044366106C81885089 @default.
• W2044366106 hasConceptScore W2044366106C86803240 @default.
• W2044366106 hasConceptScore W2044366106C95444343 @default.
• W2044366106 hasIssue "1" @default.
• W2044366106 hasLocation W20443661061 @default.
• W2044366106 hasLocation W20443661062 @default.
• W2044366106 hasOpenAccess W2044366106 @default.
• W2044366106 hasPrimaryLocation W20443661061 @default.
• W2044366106 hasRelatedWork W1971588980 @default.

• next