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- W2044366369 abstract "RATIONALE: Recent publications have suggested a possible relationship between a specific polymorphism of the β2 adrenergic receptor gene (ADRB2) and adverse effects of regular β-agonist use in subjects with asthma. Thus, individuals who are homozygous for arginine at codon 16 of the ADRB2 gene may experience a decrease in morning peak expiratory flow rate, and an increase in asthma symptoms with regular use of short or long-acting bronchodilators, with or without concomitant use of inhaled corticosteroids (Wechsler et al, Am J Respir Crit Care Med. 2006;173:519). METHODS: Poorly controlled asthmatic patients seen in the Pediatric Allergy and Immunology clinic at our center underwent genotyping of codon 16 of the ADRB2 gene using PCR with gene and polymorphism-specific primers. RESULTS: We report 3 cases of asthma in subjects with the Arg/Arg ADRB2 genotype who had poorly controlled asthma while on maintenance therapy with a combination of a high-dose inhaled corticosteroid and a daily long-acting ß2 agonist (LABA). All three patients had significant improvement in their pulmonary function tests as well as clinical symptomatology and decreased use of rescue bronchodilator medications within one month of discontinuing treatment with LABA. FEV1 pre- and post- LABA were as follows: 51% vs 102%, 66% vs 87%, and 59% vs 92%, respectively. CONCLUSIONS: Prospective randomized controlled studies are needed to confirm the possible relationship between the Arg/Arg ADRB2 genotype and potential adverse effects of regular use of β2-agonist medications." @default.
- W2044366369 created "2016-06-24" @default.
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- W2044366369 date "2007-01-01" @default.
- W2044366369 modified "2023-09-27" @default.
- W2044366369 title "Adrenergic β2 Receptor Genotyping in Asthma: Case Reports" @default.
- W2044366369 doi "https://doi.org/10.1016/j.jaci.2006.11.024" @default.
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