Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044381566> ?p ?o ?g. }
- W2044381566 endingPage "399" @default.
- W2044381566 startingPage "391" @default.
- W2044381566 abstract "The toxicity caused by cell exposure to 1-methyl-4-phenylpyridinium ion (MPP+) is a useful model in the study of Parkinson's disease (PD). However, the exact molecular mechanisms triggered by MPP+ in cell death are currently unclear. In the present research, we show that exposure to MPP+ induce the cell death of neuroblastoma-derived dopaminergic B65 cells, which is not reversed by the widely known caspase inhibitor Z-VADfmk or by calpain inhibition. Likewise, when B65 cells were treated with MPP+, the DNA damage pathway that involves p53 was activated, and cells were arrested in the G2/M phase of the cell cycle. Interestingly, MPP+ has two effects on the expression of cell cycle-related proteins. It increases the content of cyclins A, E, cdk2 and the phosphorylated form of pRb (serine 780). However, MPP+ 5 mM decreased the expression of cyclin D1, B1 and cdk4. The decrease in the expression of cyclin B1 may be related to the arrest of cells observed in the G2/M phase of cell cycle. The increase in S phase cell cycle proteins and retinoblastoma protein phosphorylation was an unexpected result. As the antioxidant trolox attenuated the process of cell loss and changes in the cell cycle, as measured by flow cytometry, we concluded that oxidative stress was involved in the effects of MPP+ in this cell line. In summary, the present work characterizes the molecular changes involved in damage caused by MPP+ in B65 cells, and highlights the effects of MPP+ on molecules involved in the control of cell cycle progression." @default.
- W2044381566 created "2016-06-24" @default.
- W2044381566 creator A5018977901 @default.
- W2044381566 creator A5026357120 @default.
- W2044381566 creator A5045978725 @default.
- W2044381566 creator A5062447911 @default.
- W2044381566 creator A5063929424 @default.
- W2044381566 creator A5073770071 @default.
- W2044381566 creator A5074978554 @default.
- W2044381566 creator A5091350606 @default.
- W2044381566 date "2010-05-01" @default.
- W2044381566 modified "2023-10-18" @default.
- W2044381566 title "Effects of MPP+ on the molecular pathways involved in cell cycle control in B65 neuroblastoma cells" @default.
- W2044381566 cites W1973552449 @default.
- W2044381566 cites W1975898641 @default.
- W2044381566 cites W1979479073 @default.
- W2044381566 cites W1979989319 @default.
- W2044381566 cites W1986519398 @default.
- W2044381566 cites W1989405078 @default.
- W2044381566 cites W1989580191 @default.
- W2044381566 cites W2011366786 @default.
- W2044381566 cites W2013139563 @default.
- W2044381566 cites W2016926246 @default.
- W2044381566 cites W2017855147 @default.
- W2044381566 cites W2027155524 @default.
- W2044381566 cites W2028377542 @default.
- W2044381566 cites W2036643127 @default.
- W2044381566 cites W2036978461 @default.
- W2044381566 cites W2043075342 @default.
- W2044381566 cites W2047160924 @default.
- W2044381566 cites W2048952420 @default.
- W2044381566 cites W2053522766 @default.
- W2044381566 cites W2053549201 @default.
- W2044381566 cites W2054415450 @default.
- W2044381566 cites W2061926052 @default.
- W2044381566 cites W2070805824 @default.
- W2044381566 cites W2071111614 @default.
- W2044381566 cites W2073914642 @default.
- W2044381566 cites W2078472322 @default.
- W2044381566 cites W2080194182 @default.
- W2044381566 cites W2083063695 @default.
- W2044381566 cites W2090060443 @default.
- W2044381566 cites W2095159036 @default.
- W2044381566 cites W2097586379 @default.
- W2044381566 cites W2098676615 @default.
- W2044381566 cites W2100252302 @default.
- W2044381566 cites W2110160400 @default.
- W2044381566 cites W2111065594 @default.
- W2044381566 cites W2114616141 @default.
- W2044381566 cites W2119976307 @default.
- W2044381566 cites W2128337365 @default.
- W2044381566 cites W2140283306 @default.
- W2044381566 cites W2142219733 @default.
- W2044381566 cites W2144662987 @default.
- W2044381566 cites W2161930186 @default.
- W2044381566 cites W2171494808 @default.
- W2044381566 cites W62603772 @default.
- W2044381566 doi "https://doi.org/10.1016/j.phrs.2010.01.003" @default.
- W2044381566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20080185" @default.
- W2044381566 hasPublicationYear "2010" @default.
- W2044381566 type Work @default.
- W2044381566 sameAs 2044381566 @default.
- W2044381566 citedByCount "9" @default.
- W2044381566 countsByYear W20443815662013 @default.
- W2044381566 countsByYear W20443815662014 @default.
- W2044381566 countsByYear W20443815662016 @default.
- W2044381566 countsByYear W20443815662017 @default.
- W2044381566 countsByYear W20443815662020 @default.
- W2044381566 crossrefType "journal-article" @default.
- W2044381566 hasAuthorship W2044381566A5018977901 @default.
- W2044381566 hasAuthorship W2044381566A5026357120 @default.
- W2044381566 hasAuthorship W2044381566A5045978725 @default.
- W2044381566 hasAuthorship W2044381566A5062447911 @default.
- W2044381566 hasAuthorship W2044381566A5063929424 @default.
- W2044381566 hasAuthorship W2044381566A5073770071 @default.
- W2044381566 hasAuthorship W2044381566A5074978554 @default.
- W2044381566 hasAuthorship W2044381566A5091350606 @default.
- W2044381566 hasConcept C105696609 @default.
- W2044381566 hasConcept C120089663 @default.
- W2044381566 hasConcept C120504264 @default.
- W2044381566 hasConcept C1491633281 @default.
- W2044381566 hasConcept C181199279 @default.
- W2044381566 hasConcept C185592680 @default.
- W2044381566 hasConcept C190283241 @default.
- W2044381566 hasConcept C2776062698 @default.
- W2044381566 hasConcept C2776715637 @default.
- W2044381566 hasConcept C2778437423 @default.
- W2044381566 hasConcept C29537977 @default.
- W2044381566 hasConcept C31573885 @default.
- W2044381566 hasConcept C54355233 @default.
- W2044381566 hasConcept C55493867 @default.
- W2044381566 hasConcept C56928146 @default.
- W2044381566 hasConcept C81885089 @default.
- W2044381566 hasConcept C86803240 @default.
- W2044381566 hasConcept C95444343 @default.
- W2044381566 hasConceptScore W2044381566C105696609 @default.
- W2044381566 hasConceptScore W2044381566C120089663 @default.
- W2044381566 hasConceptScore W2044381566C120504264 @default.