FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044381570> ?p ?o ?g. }

• W2044381570 endingPage "199" @default.
• W2044381570 startingPage "196" @default.
• W2044381570 abstract "Plasmalogens represent a unique type of phospholipids characterized by the presence of a vinyl-ether bond at the sn-1 position of the glycerol backbone. Peroxisomes are essential in their biosynthesis. Their suggested functions include protection against oxidative stress, participation in signal transduction, membrane fusion events, cholesterol transport and membrane trafficking, processes known to be disturbed in sphingolipidoses. We here report on red blood cell membrane plasmalogen levels in Gaucher disease patients. Plasmalogen levels were measured as their dimethylacetal derivatives (DMA) by gas chromatography in lipid extracts of erythrocytes from 15 patients. Their relative amount was estimated as the ratio between C18:0 DMA and methylstearate (C18:0), as well as C16:0 DMA and methylpalmitate (C16:0). Statistically significant lower levels of both plasmalogen species were observed in Gaucher disease patients compared to normal individuals. Furthermore, a negative correlation between plasmalogen levels and chitotriosidase was observed in the patients, which was statistically significant for the C18:0 species. Upon therapy, a significant rise of plasmalogen levels and fall in chitotriosidase activity was observed. However, C18:0 DMA/C18:0 was still significantly lower in Gaucher disease patients compared to controls and the negative correlation to chitotriosidase persisted. At both time points there was no indication of an overt peroxisomal dysfunction, very long chain fatty acid, phytanate and pristanate levels being normal. In conclusion, reduced plasmalogen levels that show a significant rise following treatment and a negative correlation to total disease burden, as expressed by chitotriosidase activity, are observed in Gaucher disease." @default.
• W2044381570 created "2016-06-24" @default.
• W2044381570 creator A5018853015 @default.
• W2044381570 creator A5027340645 @default.
• W2044381570 creator A5036098555 @default.
• W2044381570 creator A5055230945 @default.
• W2044381570 creator A5061352697 @default.
• W2044381570 creator A5063008957 @default.
• W2044381570 creator A5079047525 @default.
• W2044381570 date "2008-09-01" @default.
• W2044381570 modified "2023-09-25" @default.
• W2044381570 title "Plasmalogen levels in Gaucher disease" @default.
• W2044381570 cites W1938328095 @default.
• W2044381570 cites W1967818306 @default.
• W2044381570 cites W1986791752 @default.
• W2044381570 cites W1991819254 @default.
• W2044381570 cites W2005966972 @default.
• W2044381570 cites W2030962980 @default.
• W2044381570 cites W2066300584 @default.
• W2044381570 cites W2080735849 @default.
• W2044381570 cites W2107506498 @default.
• W2044381570 cites W2109302938 @default.
• W2044381570 cites W2109432887 @default.
• W2044381570 cites W2118782534 @default.
• W2044381570 cites W2123746730 @default.
• W2044381570 cites W2126108038 @default.
• W2044381570 cites W2134451042 @default.
• W2044381570 cites W2136848511 @default.
• W2044381570 cites W2138708884 @default.
• W2044381570 cites W2142409356 @default.
• W2044381570 cites W2144456776 @default.
• W2044381570 cites W2144822024 @default.
• W2044381570 cites W2160256928 @default.
• W2044381570 cites W2187003249 @default.
• W2044381570 cites W2210030840 @default.
• W2044381570 cites W4237738066 @default.
• W2044381570 doi "https://doi.org/10.1016/j.bcmd.2008.03.007" @default.
• W2044381570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18501647" @default.
• W2044381570 hasPublicationYear "2008" @default.
• W2044381570 type Work @default.
• W2044381570 sameAs 2044381570 @default.
• W2044381570 citedByCount "20" @default.
• W2044381570 countsByYear W20443815702012 @default.
• W2044381570 countsByYear W20443815702013 @default.
• W2044381570 countsByYear W20443815702014 @default.
• W2044381570 countsByYear W20443815702016 @default.
• W2044381570 countsByYear W20443815702017 @default.
• W2044381570 countsByYear W20443815702019 @default.
• W2044381570 countsByYear W20443815702022 @default.
• W2044381570 countsByYear W20443815702023 @default.
• W2044381570 crossrefType "journal-article" @default.
• W2044381570 hasAuthorship W2044381570A5018853015 @default.
• W2044381570 hasAuthorship W2044381570A5027340645 @default.
• W2044381570 hasAuthorship W2044381570A5036098555 @default.
• W2044381570 hasAuthorship W2044381570A5055230945 @default.
• W2044381570 hasAuthorship W2044381570A5061352697 @default.
• W2044381570 hasAuthorship W2044381570A5063008957 @default.
• W2044381570 hasAuthorship W2044381570A5079047525 @default.
• W2044381570 hasConcept C104317684 @default.
• W2044381570 hasConcept C126322002 @default.
• W2044381570 hasConcept C127078168 @default.
• W2044381570 hasConcept C134018914 @default.
• W2044381570 hasConcept C185592680 @default.
• W2044381570 hasConcept C2776151105 @default.
• W2044381570 hasConcept C2777565452 @default.
• W2044381570 hasConcept C2778163477 @default.
• W2044381570 hasConcept C2778918659 @default.
• W2044381570 hasConcept C2779134260 @default.
• W2044381570 hasConcept C41625074 @default.
• W2044381570 hasConcept C55493867 @default.
• W2044381570 hasConcept C71924100 @default.
• W2044381570 hasConceptScore W2044381570C104317684 @default.
• W2044381570 hasConceptScore W2044381570C126322002 @default.
• W2044381570 hasConceptScore W2044381570C127078168 @default.
• W2044381570 hasConceptScore W2044381570C134018914 @default.
• W2044381570 hasConceptScore W2044381570C185592680 @default.
• W2044381570 hasConceptScore W2044381570C2776151105 @default.
• W2044381570 hasConceptScore W2044381570C2777565452 @default.
• W2044381570 hasConceptScore W2044381570C2778163477 @default.
• W2044381570 hasConceptScore W2044381570C2778918659 @default.
• W2044381570 hasConceptScore W2044381570C2779134260 @default.
• W2044381570 hasConceptScore W2044381570C41625074 @default.
• W2044381570 hasConceptScore W2044381570C55493867 @default.
• W2044381570 hasConceptScore W2044381570C71924100 @default.
• W2044381570 hasIssue "2" @default.
• W2044381570 hasLocation W20443815701 @default.
• W2044381570 hasLocation W20443815702 @default.
• W2044381570 hasOpenAccess W2044381570 @default.
• W2044381570 hasPrimaryLocation W20443815701 @default.
• W2044381570 hasRelatedWork W1976883865 @default.
• W2044381570 hasRelatedWork W1979139803 @default.
• W2044381570 hasRelatedWork W2016341707 @default.
• W2044381570 hasRelatedWork W2035331946 @default.
• W2044381570 hasRelatedWork W2050472553 @default.
• W2044381570 hasRelatedWork W2108250029 @default.
• W2044381570 hasRelatedWork W2152596108 @default.
• W2044381570 hasRelatedWork W2399790736 @default.
• W2044381570 hasRelatedWork W2748952813 @default.

• next