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- W2044382016 abstract "Total circulatory arrest in deep hypothermia required in corrective cardiac surgery of complex congenital heart defects such as hypoplastic left heart syndrome (HLHS) in early life has been claimed to cause brain injury and altered psychomotor development. Determination of the changes in the regional intravascular concentration of oxygenated (HbO2) and deoxygenated hemoglobin (Hb) by near infrared spectroscopy (NIRS) may provide noninvasive information about change in cerebral intravascular blood oxygenation. Relative change in the redox state of the cytochromeoxydase (cyt.aa3), the terminal enzyme in the mitochondrial respiratory chain that accounts for 90% of oxygen utilization in aerobic metabolism, may provide information about the availability of oxygen at cellular level.The aim of this study therefore was to evaluate the patterns of changes in intravascular and intracellular oxygenation states in neonates with HLHS and infants with other congenital heart defects, undergoing corrective cardiac surgery using TCA in deep hypothermia." @default.
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- W2044382016 date "1999-03-02" @default.
- W2044382016 modified "2023-09-27" @default.
- W2044382016 title "Age related response of cerebral mitochondrial oxygenation in neonates and infants undergoing circulatory arrest in deep hypothermia" @default.
- W2044382016 doi "https://doi.org/10.1186/cc334" @default.
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