FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044401265> ?p ?o ?g. }

• W2044401265 abstract "Background Streptococcus mutans is known as a key causative agent of dental caries. It metabolizes dietary carbohydrate to produce acids which reduce the environmental pH leading to tooth demineralization. The ability of this bacterium to tolerate acids coupled with acid production, allows its effective colonization in the oral cavity leading to the establishment of highly cariogenic plaque. For this reason, S. mutans is the only bacterium found in significantly higher numbers than other bacteria in the dental plaque. The aim of this study was to evaluate the effect of crude extract and methanolic fraction of Z. officinale against S. mutans virulence properties.ResultsWe investigated in vitro and in vivo activity of crude extract and methanolic fraction at sub- MIC levels against cariogenic properties of S. mutans. We found that these extracts strongly inhibited a variety of virulence properties which are critical for its pathogenesis. The biofilm formation in S. mutans was found to be reduced during critical growth phases. Furthermore, the glucan synthesis and adherence was also found to be inhibited. Nevertheless, the insoluble glucan synthesis and sucrose dependent adherence were apparently more reduced as compared to soluble glucan synthesis and sucrose- independent adherence. Biofilm architecture inspected with the help of confocal and scanning electron microscopy, showed dispersion of cells in the treated group as compared to the control. The Quantitative Real Time PCR (qRT-PCR) data had shown the down regulation of the virulence genes, which is believed to be one of the major reasons responsible for the observed reduction in the virulence properties. The incredible reduction of caries development was found in treated group of rats as compared to the untreated group which further validate our in vitro data.ConclusionThe whole study concludes a prospective role of crude extract and methanolic fraction of Z. officinale in targeting complete array of cariogenic properties of S. mutans, thus reducing its pathogenesis. Hence, it may be strongly proposed as a putative anti- cariogenic agent." @default.
• W2044401265 created "2016-06-24" @default.
• W2044401265 creator A5001487177 @default.
• W2044401265 creator A5044713051 @default.
• W2044401265 creator A5067893495 @default.
• W2044401265 date "2015-01-16" @default.
• W2044401265 modified "2023-10-17" @default.
• W2044401265 title "Inhibitory effect of zingiber officinale towards Streptococcus mutans virulence and caries development: in vitro and in vivo studies" @default.
• W2044401265 cites W1495039550 @default.
• W2044401265 cites W1883937874 @default.
• W2044401265 cites W1888417066 @default.
• W2044401265 cites W1964431027 @default.
• W2044401265 cites W1967842697 @default.
• W2044401265 cites W1968029926 @default.
• W2044401265 cites W1968834637 @default.
• W2044401265 cites W1973191530 @default.
• W2044401265 cites W1980392633 @default.
• W2044401265 cites W1988483157 @default.
• W2044401265 cites W2015948328 @default.
• W2044401265 cites W2023828943 @default.
• W2044401265 cites W2027002447 @default.
• W2044401265 cites W2031385569 @default.
• W2044401265 cites W2037594004 @default.
• W2044401265 cites W2060516936 @default.
• W2044401265 cites W2065283382 @default.
• W2044401265 cites W2069785635 @default.
• W2044401265 cites W2071605785 @default.
• W2044401265 cites W2072626216 @default.
• W2044401265 cites W2077556352 @default.
• W2044401265 cites W2086808810 @default.
• W2044401265 cites W2093837393 @default.
• W2044401265 cites W2095567468 @default.
• W2044401265 cites W2104391346 @default.
• W2044401265 cites W2116893396 @default.
• W2044401265 cites W2128402268 @default.
• W2044401265 cites W2131727615 @default.
• W2044401265 cites W2143170784 @default.
• W2044401265 cites W2148337956 @default.
• W2044401265 cites W2153638667 @default.
• W2044401265 cites W2155936638 @default.
• W2044401265 cites W2164972383 @default.
• W2044401265 cites W2165240681 @default.
• W2044401265 cites W2166449119 @default.
• W2044401265 cites W2168432328 @default.
• W2044401265 doi "https://doi.org/10.1186/s12866-014-0320-5" @default.
• W2044401265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4316655" @default.
• W2044401265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25591663" @default.
• W2044401265 hasPublicationYear "2015" @default.
• W2044401265 type Work @default.
• W2044401265 sameAs 2044401265 @default.
• W2044401265 citedByCount "106" @default.
• W2044401265 countsByYear W20444012652015 @default.
• W2044401265 countsByYear W20444012652016 @default.
• W2044401265 countsByYear W20444012652017 @default.
• W2044401265 countsByYear W20444012652018 @default.
• W2044401265 countsByYear W20444012652019 @default.
• W2044401265 countsByYear W20444012652020 @default.
• W2044401265 countsByYear W20444012652021 @default.
• W2044401265 countsByYear W20444012652022 @default.
• W2044401265 countsByYear W20444012652023 @default.
• W2044401265 crossrefType "journal-article" @default.
• W2044401265 hasAuthorship W2044401265A5001487177 @default.
• W2044401265 hasAuthorship W2044401265A5044713051 @default.
• W2044401265 hasAuthorship W2044401265A5067893495 @default.
• W2044401265 hasBestOaLocation W20444012651 @default.
• W2044401265 hasConcept C104317684 @default.
• W2044401265 hasConcept C150903083 @default.
• W2044401265 hasConcept C202751555 @default.
• W2044401265 hasConcept C207001950 @default.
• W2044401265 hasConcept C2778430296 @default.
• W2044401265 hasConcept C2778597767 @default.
• W2044401265 hasConcept C2779914569 @default.
• W2044401265 hasConcept C523546767 @default.
• W2044401265 hasConcept C54355233 @default.
• W2044401265 hasConcept C55493867 @default.
• W2044401265 hasConcept C58123911 @default.
• W2044401265 hasConcept C60987743 @default.
• W2044401265 hasConcept C86803240 @default.
• W2044401265 hasConcept C89423630 @default.
• W2044401265 hasConceptScore W2044401265C104317684 @default.
• W2044401265 hasConceptScore W2044401265C150903083 @default.
• W2044401265 hasConceptScore W2044401265C202751555 @default.
• W2044401265 hasConceptScore W2044401265C207001950 @default.
• W2044401265 hasConceptScore W2044401265C2778430296 @default.
• W2044401265 hasConceptScore W2044401265C2778597767 @default.
• W2044401265 hasConceptScore W2044401265C2779914569 @default.
• W2044401265 hasConceptScore W2044401265C523546767 @default.
• W2044401265 hasConceptScore W2044401265C54355233 @default.
• W2044401265 hasConceptScore W2044401265C55493867 @default.
• W2044401265 hasConceptScore W2044401265C58123911 @default.
• W2044401265 hasConceptScore W2044401265C60987743 @default.
• W2044401265 hasConceptScore W2044401265C86803240 @default.
• W2044401265 hasConceptScore W2044401265C89423630 @default.
• W2044401265 hasIssue "1" @default.
• W2044401265 hasLocation W20444012651 @default.
• W2044401265 hasLocation W20444012652 @default.
• W2044401265 hasLocation W20444012653 @default.
• W2044401265 hasLocation W20444012654 @default.
• W2044401265 hasOpenAccess W2044401265 @default.
• W2044401265 hasPrimaryLocation W20444012651 @default.

• next