Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044405979> ?p ?o ?g. }
- W2044405979 endingPage "120" @default.
- W2044405979 startingPage "105" @default.
- W2044405979 abstract "By performing extensive pairwise structural comparisons, we recently identified a set of unique folds from the Brookhaven protein structure data bank. This analysis revealed considerable similarities between a large subgroup of the alpha+beta folds, which led us to re-examine the types of folds occurring in this class and the nature of the relationships between them.Two major alpha+beta fold groups can be distinguished. In the first, described as alpha-beta sandwiches because alpha-helices and beta-strands occupy separate and distinct layers, a split beta alpha beta motif recurs frequently. The other group, alpha-beta rolls, contains fewer helices and is more diverse. In these, the beta-sheet has folded or rolled over, providing a cradle for the alpha-helix. A beta beta beta alpha-meander motif is found throughout the alpha+beta class.Although many alpha-beta sandwiches have very similar folds, few share common functions and the active sites are distributed over the whole surface of the fold. The ability of the alpha-beta sandwich to accommodate a range of functions suggests that it is a stable fold and one that is able to adapt a number of sites to satisfy different functional requirements. In contrast, amongst the alpha-beta rolls, folds having the same roll type often have common functions." @default.
- W2044405979 created "2016-06-24" @default.
- W2044405979 creator A5068874280 @default.
- W2044405979 creator A5081250379 @default.
- W2044405979 date "1993-10-01" @default.
- W2044405979 modified "2023-10-14" @default.
- W2044405979 title "Alpha plus beta folds revisited: some favoured motifs" @default.
- W2044405979 cites W10876090 @default.
- W2044405979 cites W1506226772 @default.
- W2044405979 cites W1526216096 @default.
- W2044405979 cites W1608073189 @default.
- W2044405979 cites W1878851182 @default.
- W2044405979 cites W1880257727 @default.
- W2044405979 cites W1935237622 @default.
- W2044405979 cites W1959500134 @default.
- W2044405979 cites W1963649831 @default.
- W2044405979 cites W1966041739 @default.
- W2044405979 cites W1968434409 @default.
- W2044405979 cites W1970850106 @default.
- W2044405979 cites W1971182469 @default.
- W2044405979 cites W1972419349 @default.
- W2044405979 cites W1974684876 @default.
- W2044405979 cites W1979147581 @default.
- W2044405979 cites W1989447327 @default.
- W2044405979 cites W1989817970 @default.
- W2044405979 cites W1990077400 @default.
- W2044405979 cites W1991252389 @default.
- W2044405979 cites W1997358843 @default.
- W2044405979 cites W2000468790 @default.
- W2044405979 cites W2013946123 @default.
- W2044405979 cites W2015918625 @default.
- W2044405979 cites W2016543047 @default.
- W2044405979 cites W2019590135 @default.
- W2044405979 cites W2020716464 @default.
- W2044405979 cites W2020928707 @default.
- W2044405979 cites W2023455361 @default.
- W2044405979 cites W2023653296 @default.
- W2044405979 cites W2028094900 @default.
- W2044405979 cites W2028231353 @default.
- W2044405979 cites W2031101268 @default.
- W2044405979 cites W2034984854 @default.
- W2044405979 cites W2039616336 @default.
- W2044405979 cites W2039888163 @default.
- W2044405979 cites W2040786940 @default.
- W2044405979 cites W2040909391 @default.
- W2044405979 cites W2042452521 @default.
- W2044405979 cites W2046033652 @default.
- W2044405979 cites W2047174875 @default.
- W2044405979 cites W2051085340 @default.
- W2044405979 cites W2051989695 @default.
- W2044405979 cites W2057272352 @default.
- W2044405979 cites W2057350048 @default.
- W2044405979 cites W2057793071 @default.
- W2044405979 cites W2061124135 @default.
- W2044405979 cites W2065868722 @default.
- W2044405979 cites W2067431380 @default.
- W2044405979 cites W2069695110 @default.
- W2044405979 cites W2072814963 @default.
- W2044405979 cites W2072865985 @default.
- W2044405979 cites W2073824333 @default.
- W2044405979 cites W2074231493 @default.
- W2044405979 cites W2076264578 @default.
- W2044405979 cites W2084375199 @default.
- W2044405979 cites W2084834656 @default.
- W2044405979 cites W2099950967 @default.
- W2044405979 cites W2113403117 @default.
- W2044405979 cites W2115196876 @default.
- W2044405979 cites W2143455592 @default.
- W2044405979 cites W2154518695 @default.
- W2044405979 cites W2156012420 @default.
- W2044405979 cites W2157750263 @default.
- W2044405979 cites W4234475175 @default.
- W2044405979 cites W4237766996 @default.
- W2044405979 cites W4240414860 @default.
- W2044405979 cites W4249577843 @default.
- W2044405979 cites W4254085062 @default.
- W2044405979 cites W4299785644 @default.
- W2044405979 cites W63904086 @default.
- W2044405979 doi "https://doi.org/10.1016/0969-2126(93)90026-d" @default.
- W2044405979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8069624" @default.
- W2044405979 hasPublicationYear "1993" @default.
- W2044405979 type Work @default.
- W2044405979 sameAs 2044405979 @default.
- W2044405979 citedByCount "134" @default.
- W2044405979 countsByYear W20444059792012 @default.
- W2044405979 countsByYear W20444059792013 @default.
- W2044405979 countsByYear W20444059792014 @default.
- W2044405979 countsByYear W20444059792015 @default.
- W2044405979 countsByYear W20444059792016 @default.
- W2044405979 countsByYear W20444059792020 @default.
- W2044405979 countsByYear W20444059792021 @default.
- W2044405979 countsByYear W20444059792022 @default.
- W2044405979 countsByYear W20444059792023 @default.
- W2044405979 crossrefType "journal-article" @default.
- W2044405979 hasAuthorship W2044405979A5068874280 @default.
- W2044405979 hasAuthorship W2044405979A5081250379 @default.
- W2044405979 hasBestOaLocation W20444059791 @default.
- W2044405979 hasConcept C105795698 @default.