Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044410017> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2044410017 endingPage "369" @default.
- W2044410017 startingPage "364" @default.
- W2044410017 abstract "A novel therapy against organophosphate exposure, the combination of a carbamate eptastigmine and an organophosphate hydrolase (phosphotriesterase) was studied in mice against diisopropylfluorophosphate (DFP) (1.75 mg/kg) exposure. Mice received eptastigmine (0.9 mg/kg; iv) 10 min prior to the ip injection of DFP. Phosphotriesterase (83 U/g body weight) was injected iv 10 min after DFP. Eptastigmine (1.5 mg/kg; iv) inhibited the acetylcholinesterase activities in brain and erythrocytes for a longer time than physostigmine. Eptastigmine caused only minor changes in the behavior and activity of the animals, whereas physostigmine clearly reduced their activity for about 30 min. The eptastigmine pretreatment clearly supplemented the protective effect of phosphotriesterase against DFP: the plasma butyrylcholinesterase activity was doubled and the activity recovered faster than in animals treated with phosphotriesterase alone. In lung, butyrylcholinesterase activity was initially lower after eptastigmine–phosphotriesterase than phosphotriesterase treatment alone. However, the activity returned 24 hr later to normal in eptastigmine–phosphotries- terase-treated groups. With phosphotriesterase only, it recovered only to 75% of the control level. Presumably eptastigmine, by preventing the binding of DFP to cholinesterases, caused an elevation of free DFP levels in body fluids and promoted phosphotries- terase hydrolysis of DFP." @default.
- W2044410017 created "2016-06-24" @default.
- W2044410017 creator A5002277619 @default.
- W2044410017 creator A5004089228 @default.
- W2044410017 creator A5008224591 @default.
- W2044410017 creator A5058227565 @default.
- W2044410017 date "1996-10-01" @default.
- W2044410017 modified "2023-09-24" @default.
- W2044410017 title "Eptastigmine–Phosphotriesterase Combination in DFP Intoxication" @default.
- W2044410017 cites W147385921 @default.
- W2044410017 cites W1966636573 @default.
- W2044410017 cites W1989155649 @default.
- W2044410017 cites W2045360122 @default.
- W2044410017 cites W2399195461 @default.
- W2044410017 doi "https://doi.org/10.1006/taap.1996.0232" @default.
- W2044410017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8887453" @default.
- W2044410017 hasPublicationYear "1996" @default.
- W2044410017 type Work @default.
- W2044410017 sameAs 2044410017 @default.
- W2044410017 citedByCount "22" @default.
- W2044410017 countsByYear W20444100172013 @default.
- W2044410017 countsByYear W20444100172015 @default.
- W2044410017 countsByYear W20444100172019 @default.
- W2044410017 countsByYear W20444100172020 @default.
- W2044410017 crossrefType "journal-article" @default.
- W2044410017 hasAuthorship W2044410017A5002277619 @default.
- W2044410017 hasAuthorship W2044410017A5004089228 @default.
- W2044410017 hasAuthorship W2044410017A5008224591 @default.
- W2044410017 hasAuthorship W2044410017A5058227565 @default.
- W2044410017 hasConcept C161176658 @default.
- W2044410017 hasConcept C181199279 @default.
- W2044410017 hasConcept C185592680 @default.
- W2044410017 hasConcept C2775910092 @default.
- W2044410017 hasConcept C2776588719 @default.
- W2044410017 hasConcept C2776663719 @default.
- W2044410017 hasConcept C2776873056 @default.
- W2044410017 hasConcept C2778816929 @default.
- W2044410017 hasConcept C2779059548 @default.
- W2044410017 hasConcept C2779101902 @default.
- W2044410017 hasConcept C2779303437 @default.
- W2044410017 hasConcept C2780266723 @default.
- W2044410017 hasConcept C31896038 @default.
- W2044410017 hasConcept C55493867 @default.
- W2044410017 hasConcept C6557445 @default.
- W2044410017 hasConcept C86803240 @default.
- W2044410017 hasConcept C98274493 @default.
- W2044410017 hasConceptScore W2044410017C161176658 @default.
- W2044410017 hasConceptScore W2044410017C181199279 @default.
- W2044410017 hasConceptScore W2044410017C185592680 @default.
- W2044410017 hasConceptScore W2044410017C2775910092 @default.
- W2044410017 hasConceptScore W2044410017C2776588719 @default.
- W2044410017 hasConceptScore W2044410017C2776663719 @default.
- W2044410017 hasConceptScore W2044410017C2776873056 @default.
- W2044410017 hasConceptScore W2044410017C2778816929 @default.
- W2044410017 hasConceptScore W2044410017C2779059548 @default.
- W2044410017 hasConceptScore W2044410017C2779101902 @default.
- W2044410017 hasConceptScore W2044410017C2779303437 @default.
- W2044410017 hasConceptScore W2044410017C2780266723 @default.
- W2044410017 hasConceptScore W2044410017C31896038 @default.
- W2044410017 hasConceptScore W2044410017C55493867 @default.
- W2044410017 hasConceptScore W2044410017C6557445 @default.
- W2044410017 hasConceptScore W2044410017C86803240 @default.
- W2044410017 hasConceptScore W2044410017C98274493 @default.
- W2044410017 hasIssue "2" @default.
- W2044410017 hasLocation W20444100171 @default.
- W2044410017 hasLocation W20444100172 @default.
- W2044410017 hasOpenAccess W2044410017 @default.
- W2044410017 hasPrimaryLocation W20444100171 @default.
- W2044410017 hasRelatedWork W100681284 @default.
- W2044410017 hasRelatedWork W1008243866 @default.
- W2044410017 hasRelatedWork W1985215852 @default.
- W2044410017 hasRelatedWork W2025370358 @default.
- W2044410017 hasRelatedWork W2044410017 @default.
- W2044410017 hasRelatedWork W2045314599 @default.
- W2044410017 hasRelatedWork W2080961398 @default.
- W2044410017 hasRelatedWork W2093085472 @default.
- W2044410017 hasRelatedWork W2141592420 @default.
- W2044410017 hasRelatedWork W235450312 @default.
- W2044410017 hasVolume "140" @default.
- W2044410017 isParatext "false" @default.
- W2044410017 isRetracted "false" @default.
- W2044410017 magId "2044410017" @default.
- W2044410017 workType "article" @default.