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• W2044418072 abstract "The extent of covalent binding to plasma proteins, hemoglobin and guanine-N-7 in DNA was determined after intraperitoneal administration of radiolabelled styrene and styrene-7,8-oxide to mice. The degree of alkylation increased non-linearly with the dose. It was proportionally higher after the highest doses of styrene-7,8-oxide while the reverse was observed with respect to the ability of styrene to alkylate plasma proteins and DNA. Thus, a dose dependence was indicated in the elimination of both styrene and styrene-7,8-oxide. A comparison of the degree of alkylation of plasma proteins, hemoglobin and guanine-N-7 in DNA suggests that the two compounds are about equally effective as alkylating agents in vivo at moderate dose levels. At high doses styrene-7,8-oxide is the more effective alkylator. The alkylation of DNA in liver, brain and lung after administration of styrene-7,8-oxide exceeded that in spleen and testis." @default.
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• W2044418072 date "1985-01-01" @default.
• W2044418072 modified "2023-09-27" @default.
• W2044418072 title "Covalent binding of styrene and styrene-7,8-oxide to plasma proteins, hemoglobin and dna in the mouse" @default.
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• W2044418072 doi "https://doi.org/10.1016/s0009-2797(85)80120-4" @default.
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