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- W2044419156 abstract "A putative crayfish iron-responsive element (IRE) is present in the 5′-untranslated region of the crayfish ferritin mRNA. The putative crayfish IRE is in a cap-proximal position and shares most of the structural features of the consensus IRE, but the RNA stem-loop structure contains a bulge of a guanine instead of a cytosine at the expected position, so far thought to be a hallmark of IREs. By using an electromobility shift assay this IRE was shown to specifically bind purified recombinant human iron regulatory protein 1 (IRP1) as well as a factor(s) present in a homogenate of crayfish hepatopancreas, likely to be a crayfish IRP1 homologue. With mutations in the crayfish IRE, the affinity of IRP to IRE was drastically decreased. A cDNA2 encoding an IRP1-like protein was cloned from the hepatopancreas of crayfish. This protein has sequence similarities to IRP1, and contains all the active-site residues of aconitase, two putative RNA-binding regions and a putative contact site between RNA and IRP. These results show that a crayfish IRE, lacking the bulged C, can bind IRP1 in vitro and that an IRP1-like protein present in crayfish hepatopancreas may have both aconitase and RNA-binding activities." @default.
- W2044419156 created "2016-06-24" @default.
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- W2044419156 date "1999-01-01" @default.
- W2044419156 modified "2023-10-15" @default.
- W2044419156 title "An atypical Iron-Responsive Element (IRE) within crayfish ferritin mRNA and an Iron Regulatory Protein 1 (IRP1)-like protein from crayfish hepatopancreas" @default.
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- W2044419156 doi "https://doi.org/10.1016/s0965-1748(98)00097-6" @default.
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