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- W2044424022 abstract "1. In a cell suspension culture of tomato (Lycopersicon esculentum cv. Lukullus) and in E. gracilis the uracil taken up is irreversibly degraded to CO2, NH3, and β-alanine by the reductive pathway. 2. In both organisms, the rate-limiting step of uracil degradation was examined by various in vivo experiments. 3. For E. gracilis, the reductive pyrimidine degradation was extensively investigated before (Molec. Cell. Biol. 3, 613, 1983). 4. Studying tomato cells, different concentrations of [2-14C]uracil or its subsequent catabolite [2-14C]dihydrouracil were applied and the fate of both metabolites analyzed. 5. The uptake and breakdown of dihydrouracil were enhanced over a wide range of increasing extracellular concentrations up to 1 mM, whereas increasing amounts of uracil taken up were not degraded. 6. Preincubation with dihydrouracil resulted in an inactive trap for labeled catabolites originating from [2-14C]uracil. 7. On the contrary, preincubation with unlabeled uracil did not interfere with the breakdown of [2-14C]dihydrouracil. 8. This and further results on uptake and metabolic conversions of uracil and dihydrouracil suggest the uracil reduction as a rate-limiting step in reductive pyrimidine catabolism of tomato cells. 9. Using a similar approach, the same conclusion was drawn from the studies on Euglena gracilis. 10. The lack of accumulation of intermediates, the failure of an influence of pyrimidines on dihydrouracil degradation and the slopes of the v/s curves for the CO2 release measured in vivo for each of the three involved metabolites confirm a rate-limiting function of the reduction step." @default.
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- W2044424022 title "The rate-limiting step of uracil degradation in tomato cell suspension cultures and Euglena gracilis in vivo studies" @default.
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- W2044424022 doi "https://doi.org/10.1016/0305-0491(85)90526-7" @default.
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