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- W2044425580 abstract "To the Editor.— Simmons and Stolley refer to shift of the bacterial ecological equilibrium to selectively ecovor the Gram-negative organisms. But the commentary en bloc does not emphasize and analyze the microbiological basis of the Gram-negative bacterial disease problem. This omission is regrettable because the problem, once generated, may not readily disappear in response to legislative or committee actions. A large part of the problem is multiple chemotherapeutic drug resistance of Gram-negative bacteria. During the first two decades of the sulfonamide-antibiotic era, bacterial resistance to single chemotherapeutic drugs was seen as the result of selective breeding of spontaneous chromosomal bacterial mutants under drug pressure. This entailed cross-resistance only to drugs that were closely related in chemical structure and mechanism of action. The last decade, however, has witnessed a worldwide emergence of multiresistance of Gram-negative bacteria caused by extrachromosomal elements of bacterial heredity, the R-factors. Under pressure of one drug," @default.
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- W2044425580 date "1974-05-27" @default.
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- W2044425580 title "Trends of Antibiotic Use In the United States" @default.
- W2044425580 doi "https://doi.org/10.1001/jama.1974.03230340014012" @default.
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