Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044428616> ?p ?o ?g. }
- W2044428616 abstract "α-Synuclein is a presynaptic protein that is implicated in Parkinson's and other neurodegenerative diseases. Physiologically, native α-synuclein promotes presynaptic SNARE-complex assembly, but its molecular mechanism of action remains unknown. Here, we found that native α-synuclein promotes clustering of synaptic-vesicle mimics, using a single-vesicle optical microscopy system. This vesicle-clustering activity was observed for both recombinant and native α-synuclein purified from mouse brain. Clustering was dependent on specific interactions of native α-synuclein with both synaptobrevin-2/VAMP2 and anionic lipids. Out of the three familial Parkinson's disease-related point mutants of α-synuclein, only the lipid-binding deficient mutation A30P disrupted clustering, hinting at a possible loss of function phenotype for this mutant. α-Synuclein had little effect on Ca(2+)-triggered fusion in our reconstituted single-vesicle system, consistent with in vivo data. α-Synuclein may therefore lead to accumulation of synaptic vesicles at the active zone, providing a 'buffer' of synaptic vesicles, without affecting neurotransmitter release itself. DOI:http://dx.doi.org/10.7554/eLife.00592.001." @default.
- W2044428616 created "2016-06-24" @default.
- W2044428616 creator A5000219144 @default.
- W2044428616 creator A5018513716 @default.
- W2044428616 creator A5019402916 @default.
- W2044428616 creator A5020510051 @default.
- W2044428616 creator A5039737636 @default.
- W2044428616 creator A5061921730 @default.
- W2044428616 creator A5083605618 @default.
- W2044428616 creator A5088496875 @default.
- W2044428616 date "2013-04-30" @default.
- W2044428616 modified "2023-10-16" @default.
- W2044428616 title "Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2" @default.
- W2044428616 cites W1502551601 @default.
- W2044428616 cites W1517181973 @default.
- W2044428616 cites W1527671059 @default.
- W2044428616 cites W1844422703 @default.
- W2044428616 cites W1965573624 @default.
- W2044428616 cites W1965778124 @default.
- W2044428616 cites W1972715091 @default.
- W2044428616 cites W1979944790 @default.
- W2044428616 cites W1990473626 @default.
- W2044428616 cites W2002768329 @default.
- W2044428616 cites W2007521423 @default.
- W2044428616 cites W2009573330 @default.
- W2044428616 cites W2013593979 @default.
- W2044428616 cites W2015784694 @default.
- W2044428616 cites W2017040646 @default.
- W2044428616 cites W2022046189 @default.
- W2044428616 cites W2022428567 @default.
- W2044428616 cites W2023245921 @default.
- W2044428616 cites W2024281265 @default.
- W2044428616 cites W2030564316 @default.
- W2044428616 cites W2040706104 @default.
- W2044428616 cites W2041134571 @default.
- W2044428616 cites W2044141286 @default.
- W2044428616 cites W2050786534 @default.
- W2044428616 cites W2052204832 @default.
- W2044428616 cites W2052975546 @default.
- W2044428616 cites W2059527306 @default.
- W2044428616 cites W2061216302 @default.
- W2044428616 cites W2069491212 @default.
- W2044428616 cites W2073058641 @default.
- W2044428616 cites W2074649216 @default.
- W2044428616 cites W2075927534 @default.
- W2044428616 cites W2076042026 @default.
- W2044428616 cites W2077881833 @default.
- W2044428616 cites W2079324871 @default.
- W2044428616 cites W2080566347 @default.
- W2044428616 cites W2081032574 @default.
- W2044428616 cites W2085082653 @default.
- W2044428616 cites W2091265794 @default.
- W2044428616 cites W2093861673 @default.
- W2044428616 cites W2100102456 @default.
- W2044428616 cites W2102436080 @default.
- W2044428616 cites W2104061091 @default.
- W2044428616 cites W2106246537 @default.
- W2044428616 cites W2123184492 @default.
- W2044428616 cites W2123431154 @default.
- W2044428616 cites W2130323165 @default.
- W2044428616 cites W2136429865 @default.
- W2044428616 cites W2136956472 @default.
- W2044428616 cites W2137606977 @default.
- W2044428616 cites W2138375082 @default.
- W2044428616 cites W2144737808 @default.
- W2044428616 cites W2150656456 @default.
- W2044428616 cites W2151858671 @default.
- W2044428616 cites W2153536347 @default.
- W2044428616 cites W2154737306 @default.
- W2044428616 cites W2155477793 @default.
- W2044428616 cites W2158350205 @default.
- W2044428616 cites W2161334375 @default.
- W2044428616 cites W2171281715 @default.
- W2044428616 cites W2768578200 @default.
- W2044428616 doi "https://doi.org/10.7554/elife.00592" @default.
- W2044428616 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3639508" @default.
- W2044428616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23638301" @default.
- W2044428616 hasPublicationYear "2013" @default.
- W2044428616 type Work @default.
- W2044428616 sameAs 2044428616 @default.
- W2044428616 citedByCount "262" @default.
- W2044428616 countsByYear W20444286162012 @default.
- W2044428616 countsByYear W20444286162013 @default.
- W2044428616 countsByYear W20444286162014 @default.
- W2044428616 countsByYear W20444286162015 @default.
- W2044428616 countsByYear W20444286162016 @default.
- W2044428616 countsByYear W20444286162017 @default.
- W2044428616 countsByYear W20444286162018 @default.
- W2044428616 countsByYear W20444286162019 @default.
- W2044428616 countsByYear W20444286162020 @default.
- W2044428616 countsByYear W20444286162021 @default.
- W2044428616 countsByYear W20444286162022 @default.
- W2044428616 countsByYear W20444286162023 @default.
- W2044428616 crossrefType "journal-article" @default.
- W2044428616 hasAuthorship W2044428616A5000219144 @default.
- W2044428616 hasAuthorship W2044428616A5018513716 @default.
- W2044428616 hasAuthorship W2044428616A5019402916 @default.
- W2044428616 hasAuthorship W2044428616A5020510051 @default.
- W2044428616 hasAuthorship W2044428616A5039737636 @default.
- W2044428616 hasAuthorship W2044428616A5061921730 @default.