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- W2044431386 abstract "Membrane rafts (MRs) are clusters of lipids, organized in a “quasicrystalline” liquid-order phase, organized on the cell surface and whose pattern of molecules and physicochemical properties are distinct from those of the surrounding plasma membrane. MRs may be considered an efficient and fairly rapid cell-activated mechanism to express or mask surface receptors aimed at triggering specific response pathways. This paper reports observations concerning the role of MRs in the control of lung extravascular water that ought to be kept at minimum to assure gas diffusion, supporting the hypothesis that MRs expression is a potential mechanism of sensing minor changes in the volume of extravascular water. We present the evidence that MRs expression specifically relates to signal-transduction processes evoked by mechanical stimuli arising in the interstitial lung compartment when a small increase in extravascular volume occurs. We further hypothesize that a differential expression of MRs might also reflect the damage to precise components of the extracellular matrix caused by the perturbation in water balance and thus can trigger a molecule-oriented specific matrix remodelling." @default.
- W2044431386 created "2016-06-24" @default.
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- W2044431386 creator A5060024119 @default.
- W2044431386 creator A5068621814 @default.
- W2044431386 creator A5079166399 @default.
- W2044431386 date "2011-01-01" @default.
- W2044431386 modified "2023-10-16" @default.
- W2044431386 title "Remodelling of Membrane Rafts Expression in Lung Cells as an Early Sign of Mechanotransduction-Signalling in Pulmonary Edema" @default.
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- W2044431386 doi "https://doi.org/10.1155/2011/695369" @default.
- W2044431386 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3139192" @default.
- W2044431386 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21785732" @default.
- W2044431386 hasPublicationYear "2011" @default.
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