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- W2044432786 abstract "The effect of severe hypoxia on the vascular tone of isolated rat aortic rings with and without endothelium was studied. Hypoxia induced transient contractions that were significantly more pronounced in preparations with endothelium. These responses were reproducible during two consecutive episodes of hypoxia. With increasing concentrations of phenylephrine (EC 10 to EC 100) the amplitude of endothelium-dependent hypoxic contractions decreased. Indomethacin, the inhibitor of cyclooxygenase, had no effect on hypoxic contractions whereas substances that decrease the cyclic GMP content of vascular smooth muscle cells (methylene blue, nitro-L-arginine) inhibited hypoxic contractions. M&B 22948, a substance that increases the cyclic GMP level, augmented hypoxic contractions. Low concentrations of exogenous donors of nitric oxide (sodium nitroprusside, SIN-1) caused the appearance or significantly augmented hypoxic contractions in preparations without endothelium. This was not observed with the cyclic AMP-depen..." @default.
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- W2044432786 title "Hypoxic Contraction in Isolated Rat Abdominal Aorta: Role of Endothelium and Vascular Smooth Muscle" @default.
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