FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044433020> ?p ?o ?g. }

• W2044433020 endingPage "4304" @default.
• W2044433020 startingPage "4296" @default.
• W2044433020 abstract "We demonstrate a general role for DNA replication in the activation of gene transcription in transient transfection assays. The effect is observed for a wide range of genes and cell types, transfected by a number of protocols and is independent of increased template copy number. Replication does not stimulate transcription driven by proximal promoter elements alone but requires a functional enhancer element. This synergy between an active replication origin and an enhancer is not confined to elements from viruses such as SV40, which undergo an early to late switch in gene expression that is tightly coupled to replication, since the enhancer-containing long terminal repeats from retroviruses are strongly stimulated by replication. Furthermore, synthetic enhancers consisting of multimerised binding sites for one or two factors are also subject to replication-activation. The diversity of synthetic and natural enhancers used in this study suggests that replication and transcription do not share a common protein factor. We propose that replication leads to chromatin modifications that facilitate enhancer action." @default.
• W2044433020 created "2016-06-24" @default.
• W2044433020 creator A5034902241 @default.
• W2044433020 creator A5047824283 @default.
• W2044433020 date "1993-01-01" @default.
• W2044433020 modified "2023-10-16" @default.
• W2044433020 title "DNA replication facilitates the action of transcriptional enhancers in transient expression assays" @default.
• W2044433020 cites W1217246038 @default.
• W2044433020 cites W1542224114 @default.
• W2044433020 cites W174331424 @default.
• W2044433020 cites W1778470944 @default.
• W2044433020 cites W1852163320 @default.
• W2044433020 cites W1889649309 @default.
• W2044433020 cites W1904002403 @default.
• W2044433020 cites W1938717805 @default.
• W2044433020 cites W1964290387 @default.
• W2044433020 cites W1986160949 @default.
• W2044433020 cites W1989887575 @default.
• W2044433020 cites W1995608753 @default.
• W2044433020 cites W1997086574 @default.
• W2044433020 cites W2002873026 @default.
• W2044433020 cites W2010353576 @default.
• W2044433020 cites W2010356985 @default.
• W2044433020 cites W2015669100 @default.
• W2044433020 cites W2016103382 @default.
• W2044433020 cites W2016456601 @default.
• W2044433020 cites W2018117114 @default.
• W2044433020 cites W2030211226 @default.
• W2044433020 cites W2033466465 @default.
• W2044433020 cites W2034279963 @default.
• W2044433020 cites W2045057703 @default.
• W2044433020 cites W2045583364 @default.
• W2044433020 cites W2056107617 @default.
• W2044433020 cites W2058212923 @default.
• W2044433020 cites W2059841926 @default.
• W2044433020 cites W2065355676 @default.
• W2044433020 cites W2070159701 @default.
• W2044433020 cites W2080766637 @default.
• W2044433020 cites W2088167128 @default.
• W2044433020 cites W2106977971 @default.
• W2044433020 cites W2108227789 @default.
• W2044433020 cites W2130109620 @default.
• W2044433020 cites W2134812217 @default.
• W2044433020 cites W2144206181 @default.
• W2044433020 cites W2163597572 @default.
• W2044433020 cites W2173492637 @default.
• W2044433020 cites W2219617001 @default.
• W2044433020 cites W2233385445 @default.
• W2044433020 cites W2409227287 @default.
• W2044433020 cites W54353042 @default.
• W2044433020 doi "https://doi.org/10.1093/nar/21.18.4296" @default.
• W2044433020 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/310064" @default.
• W2044433020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8414985" @default.
• W2044433020 hasPublicationYear "1993" @default.
• W2044433020 type Work @default.
• W2044433020 sameAs 2044433020 @default.
• W2044433020 citedByCount "10" @default.
• W2044433020 countsByYear W20444330202013 @default.
• W2044433020 crossrefType "journal-article" @default.
• W2044433020 hasAuthorship W2044433020A5034902241 @default.
• W2044433020 hasAuthorship W2044433020A5047824283 @default.
• W2044433020 hasBestOaLocation W20444330202 @default.
• W2044433020 hasConcept C104317684 @default.
• W2044433020 hasConcept C104690221 @default.
• W2044433020 hasConcept C111936080 @default.
• W2044433020 hasConcept C138885662 @default.
• W2044433020 hasConcept C151158763 @default.
• W2044433020 hasConcept C153911025 @default.
• W2044433020 hasConcept C175193931 @default.
• W2044433020 hasConcept C179926584 @default.
• W2044433020 hasConcept C188036394 @default.
• W2044433020 hasConcept C21784809 @default.
• W2044433020 hasConcept C41141232 @default.
• W2044433020 hasConcept C41895202 @default.
• W2044433020 hasConcept C54266558 @default.
• W2044433020 hasConcept C54355233 @default.
• W2044433020 hasConcept C58337764 @default.
• W2044433020 hasConcept C73573662 @default.
• W2044433020 hasConcept C83640560 @default.
• W2044433020 hasConcept C86339819 @default.
• W2044433020 hasConcept C86803240 @default.
• W2044433020 hasConcept C95444343 @default.
• W2044433020 hasConcept C98086919 @default.
• W2044433020 hasConceptScore W2044433020C104317684 @default.
• W2044433020 hasConceptScore W2044433020C104690221 @default.
• W2044433020 hasConceptScore W2044433020C111936080 @default.
• W2044433020 hasConceptScore W2044433020C138885662 @default.
• W2044433020 hasConceptScore W2044433020C151158763 @default.
• W2044433020 hasConceptScore W2044433020C153911025 @default.
• W2044433020 hasConceptScore W2044433020C175193931 @default.
• W2044433020 hasConceptScore W2044433020C179926584 @default.
• W2044433020 hasConceptScore W2044433020C188036394 @default.
• W2044433020 hasConceptScore W2044433020C21784809 @default.
• W2044433020 hasConceptScore W2044433020C41141232 @default.
• W2044433020 hasConceptScore W2044433020C41895202 @default.
• W2044433020 hasConceptScore W2044433020C54266558 @default.
• W2044433020 hasConceptScore W2044433020C54355233 @default.
• W2044433020 hasConceptScore W2044433020C58337764 @default.

• next