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- W2044436893 abstract "Synthetic cathinones, colloquially referred to as “bath salts,” are derivatives of the psychoactive alkaloid cathinone found in Catha edulis (Khat). Since the mid-to-late 2000s, these amphetamine-like psychostimulants have gained popularity amongst drug users due to their potency, low cost, ease of procurement, and constantly evolving chemical structures. Concomitant with their increased use is the emergence of a growing collection of case reports of bizarre and dangerous behaviors, toxicity to numerous organ systems, and death. However, scientific information regarding the abuse liability of these drugs has been relatively slower to materialize. Recently we have published several studies demonstrating that laboratory rodents will readily self-administer the “first generation” synthetic cathinones methylenedioxypyrovalerone (MDPV) and methylone via the intravenous route, in patterns similar to those of methamphetamine. Under progressive ratio schedules of reinforcement, the rank order of reinforcing efficacy of these compounds is MDPV ≥ methamphetamine > methylone. MDPV and methylone, as well as the “second generation” synthetic cathinones α -pyrrolidinovalerophenone ( α -PVP) and 4-methylethcathinone (4-MEC), also dose-dependently increase brain reward function. Collectively, these findings indicate that synthetic cathinones have a high abuse and addiction potential and underscore the need for future assessment of the extent and duration of neurotoxicity induced by these emerging drugs of abuse." @default.
- W2044436893 created "2016-06-24" @default.
- W2044436893 creator A5071580361 @default.
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- W2044436893 date "2014-06-04" @default.
- W2044436893 modified "2023-09-29" @default.
- W2044436893 title "Synthetic Cathinones and Their Rewarding and Reinforcing Effects in Rodents" @default.
- W2044436893 cites W1479855792 @default.
- W2044436893 cites W1515846206 @default.
- W2044436893 cites W1561492980 @default.
- W2044436893 cites W1572907996 @default.
- W2044436893 cites W1852587300 @default.
- W2044436893 cites W1871259069 @default.
- W2044436893 cites W1975432588 @default.
- W2044436893 cites W1977878669 @default.
- W2044436893 cites W1985053470 @default.
- W2044436893 cites W1991718370 @default.
- W2044436893 cites W1995219666 @default.
- W2044436893 cites W2001865657 @default.
- W2044436893 cites W2007101824 @default.
- W2044436893 cites W2007959075 @default.
- W2044436893 cites W2009308188 @default.
- W2044436893 cites W2009548493 @default.
- W2044436893 cites W2017187845 @default.
- W2044436893 cites W2017404713 @default.
- W2044436893 cites W2020047442 @default.
- W2044436893 cites W2025440394 @default.
- W2044436893 cites W2025858889 @default.
- W2044436893 cites W2027763607 @default.
- W2044436893 cites W2027931582 @default.
- W2044436893 cites W2028784398 @default.
- W2044436893 cites W2028937126 @default.
- W2044436893 cites W2038738168 @default.
- W2044436893 cites W2041614065 @default.
- W2044436893 cites W2045216650 @default.
- W2044436893 cites W2053414348 @default.
- W2044436893 cites W2058200713 @default.
- W2044436893 cites W2058204783 @default.
- W2044436893 cites W2058573278 @default.
- W2044436893 cites W2066848874 @default.
- W2044436893 cites W2071513980 @default.
- W2044436893 cites W2073890140 @default.
- W2044436893 cites W2074378176 @default.
- W2044436893 cites W2078716429 @default.
- W2044436893 cites W2080832766 @default.
- W2044436893 cites W2084502769 @default.
- W2044436893 cites W2085274629 @default.
- W2044436893 cites W2089028351 @default.
- W2044436893 cites W2089312873 @default.
- W2044436893 cites W2089762590 @default.
- W2044436893 cites W2093059002 @default.
- W2044436893 cites W2095103635 @default.
- W2044436893 cites W2101949675 @default.
- W2044436893 cites W2102271024 @default.
- W2044436893 cites W2108264967 @default.
- W2044436893 cites W2111539014 @default.
- W2044436893 cites W2115253791 @default.
- W2044436893 cites W2125965195 @default.
- W2044436893 cites W2126855384 @default.
- W2044436893 cites W2131480578 @default.
- W2044436893 cites W2133396498 @default.
- W2044436893 cites W2135124613 @default.
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- W2044436893 cites W2145587240 @default.
- W2044436893 cites W2149493410 @default.
- W2044436893 cites W2155241775 @default.
- W2044436893 cites W2159885230 @default.
- W2044436893 cites W2163582349 @default.
- W2044436893 cites W2164867125 @default.
- W2044436893 cites W2166720276 @default.
- W2044436893 cites W2167085007 @default.
- W2044436893 cites W2168297713 @default.
- W2044436893 cites W2171635507 @default.
- W2044436893 cites W2318384381 @default.
- W2044436893 cites W2327030204 @default.
- W2044436893 cites W2345342372 @default.
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- W2044436893 doi "https://doi.org/10.1155/2014/209875" @default.
- W2044436893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4199755" @default.
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