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- W2044437961 abstract "Worldwide, millions of people with treated hypertension fail to reach optimum blood pressures. Some fail because they are receiving less medication than they need and others will not be adhering to treatment. Another substantial group of patients have resistant hypertension—ie, they are difficult to treat-to-target despite optimum doses of at least three different classes of antihypertensives, one of which is usually a thiazide diuretic. 1 Calhoun DA Jones D Trextor S et al. Resistant hypertension: diagnosis, evaluation, and treatment. a scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Hypertension. 2008; 51: 1403-1419 Crossref PubMed Scopus (1249) Google Scholar To optimise reduction in blood pressure, this definition could be extended to: a rational combination of three antihypertensives that would usually include a thiazide, a calcium-channel blocker, and a blocker of the renin–angiotensin system in optimum best-tolerated doses. A selective endothelin-receptor antagonist to reduce blood pressure in patients with treatment-resistant hypertension: a randomised, double-blind, placebo-controlled trialDarusentan provides additional reduction in blood pressure in patients who have not attained their treatment goals with three or more antihypertensive drugs. As with other vasodilatory drugs, fluid management with effective diuretic therapy might be needed. Full-Text PDF" @default.
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- W2044437961 date "2009-10-01" @default.
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- W2044437961 title "Resistant hypertension: an unmet treatment need" @default.
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- W2044437961 doi "https://doi.org/10.1016/s0140-6736(09)61600-7" @default.
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