FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044438488> ?p ?o ?g. }

• W2044438488 abstract "Aging has been associated with glucose intolerance, insulin resistance, hyperinsulinemia, and diminished islet B-cell function. The relative contribution of these factors to the aging-associated changes in glucose tolerance has been difficult to discern, particularly so for B-cell function, since insulin sensitivity itself is a determinant of B-cell function and, therefore, comparisons of insulin levels and responses between old and young subjects are difficult. To reduce this effect, we compared B-cell function in 14 healthy older men (aged 61-82 yr; body mass index, 21-30 kg/m2), who were exercise trained for 6 months to improve insulin sensitivity, to that of 11 healthy young men (aged 24-31 yr; body mass index, 19-31 kg/m2), who were also trained. Insulin-glucose interactions were assessed by measuring indices of insulin sensitivity (SI) and glucose effectiveness at zero insulin (GEZI) using Bergman's minimal model. B-Cell function was assessed by determining the acute insulin responses (AIR) to glucose (AIRgluc) and arginine at 3 different glucose levels: fasting, approximately 14 mM, and greater than 28 mM (AIRmax). AIRmax provides a measure of B-cell secretory capacity, while the glucose level at which 50% of AIRmax occurs is termed PG50 and is used to estimate B-cell sensitivity to glucose. The insulin sensitivity and glucose effectiveness at zero insulin of the trained older subjects was similar to that of the trained young [SI: old, 5.1 +/- 0.6; young, 6.5 +/- 0.7 x 10(-5) min-1/pM (mean +/- SEM; P = NS); GEZI: old, 1.3 +/- 0.2; young, 1.7 +/- 0.2 x 10(-2) min (P = NS)]. Under these conditions, the fasting glucose levels (old, 5.4 +/- 0.2; young, 5.1 +/- 0.1 mM) and basal insulin levels (old, 49 +/- 6; young, 63 +/- 11 pM) were also similar in the two groups. AIRgluc values were lower in the exercised elderly (old, 253 +/- 50; young, 543 +/- 101 pM; P = 0.01). This decrease in stimulated insulin release was due solely to a reduction in the AIRmax (old, 1277 +/- 179; young, 2321 +/- 225 pM; P less than 0.005); the PG50 was not different (old, 8.9 +/- 0.4; young, 8.8 +/- 0.2 mM; P = NS). These differences in the older subjects were associated with a reduction in iv glucose tolerance (old, 1.49 +/- 0.15; young, 1.95 +/- 0.13%/min; P less than 0.05).(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W2044438488 created "2016-06-24" @default.
• W2044438488 creator A5002247535 @default.
• W2044438488 creator A5024413943 @default.
• W2044438488 creator A5033064216 @default.
• W2044438488 creator A5037277140 @default.
• W2044438488 creator A5039095657 @default.
• W2044438488 creator A5051142287 @default.
• W2044438488 creator A5074064171 @default.
• W2044438488 creator A5081397975 @default.
• W2044438488 creator A5088425806 @default.
• W2044438488 date "1992-06-01" @default.
• W2044438488 modified "2023-09-26" @default.
• W2044438488 title "Exercise training delineates the importance of B-cell dysfunction to the glucose intolerance of human aging." @default.
• W2044438488 cites W1965609036 @default.
• W2044438488 cites W1969683709 @default.
• W2044438488 cites W1977797609 @default.
• W2044438488 cites W1979102029 @default.
• W2044438488 cites W2010370721 @default.
• W2044438488 cites W2032594496 @default.
• W2044438488 cites W2037808521 @default.
• W2044438488 cites W2047397124 @default.
• W2044438488 cites W2054293703 @default.
• W2044438488 cites W2056966934 @default.
• W2044438488 cites W2083712438 @default.
• W2044438488 cites W2098578065 @default.
• W2044438488 cites W2100795674 @default.
• W2044438488 cites W2115804269 @default.
• W2044438488 cites W2130171861 @default.
• W2044438488 cites W2168588540 @default.
• W2044438488 cites W2177289299 @default.
• W2044438488 cites W2295768070 @default.
• W2044438488 cites W2314772705 @default.
• W2044438488 cites W2319180293 @default.
• W2044438488 cites W2419281905 @default.
• W2044438488 cites W2471353690 @default.
• W2044438488 cites W3126638858 @default.
• W2044438488 doi "https://doi.org/10.1210/jcem.74.6.1592879" @default.
• W2044438488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1592879" @default.
• W2044438488 hasPublicationYear "1992" @default.
• W2044438488 type Work @default.
• W2044438488 sameAs 2044438488 @default.
• W2044438488 citedByCount "20" @default.
• W2044438488 countsByYear W20444384882018 @default.
• W2044438488 countsByYear W20444384882019 @default.
• W2044438488 countsByYear W20444384882020 @default.
• W2044438488 countsByYear W20444384882021 @default.
• W2044438488 countsByYear W20444384882022 @default.
• W2044438488 crossrefType "journal-article" @default.
• W2044438488 hasAuthorship W2044438488A5002247535 @default.
• W2044438488 hasAuthorship W2044438488A5024413943 @default.
• W2044438488 hasAuthorship W2044438488A5033064216 @default.
• W2044438488 hasAuthorship W2044438488A5037277140 @default.
• W2044438488 hasAuthorship W2044438488A5039095657 @default.
• W2044438488 hasAuthorship W2044438488A5051142287 @default.
• W2044438488 hasAuthorship W2044438488A5074064171 @default.
• W2044438488 hasAuthorship W2044438488A5081397975 @default.
• W2044438488 hasAuthorship W2044438488A5088425806 @default.
• W2044438488 hasConcept C126322002 @default.
• W2044438488 hasConcept C134018914 @default.
• W2044438488 hasConcept C165220095 @default.
• W2044438488 hasConcept C2777391703 @default.
• W2044438488 hasConcept C2779306644 @default.
• W2044438488 hasConcept C2780221984 @default.
• W2044438488 hasConcept C2780352109 @default.
• W2044438488 hasConcept C2780833929 @default.
• W2044438488 hasConcept C2780988686 @default.
• W2044438488 hasConcept C3017594256 @default.
• W2044438488 hasConcept C71924100 @default.
• W2044438488 hasConceptScore W2044438488C126322002 @default.
• W2044438488 hasConceptScore W2044438488C134018914 @default.
• W2044438488 hasConceptScore W2044438488C165220095 @default.
• W2044438488 hasConceptScore W2044438488C2777391703 @default.
• W2044438488 hasConceptScore W2044438488C2779306644 @default.
• W2044438488 hasConceptScore W2044438488C2780221984 @default.
• W2044438488 hasConceptScore W2044438488C2780352109 @default.
• W2044438488 hasConceptScore W2044438488C2780833929 @default.
• W2044438488 hasConceptScore W2044438488C2780988686 @default.
• W2044438488 hasConceptScore W2044438488C3017594256 @default.
• W2044438488 hasConceptScore W2044438488C71924100 @default.
• W2044438488 hasLocation W20444384881 @default.
• W2044438488 hasLocation W20444384882 @default.
• W2044438488 hasOpenAccess W2044438488 @default.
• W2044438488 hasPrimaryLocation W20444384881 @default.
• W2044438488 hasRelatedWork W1924100335 @default.
• W2044438488 hasRelatedWork W2012273189 @default.
• W2044438488 hasRelatedWork W2014369012 @default.
• W2044438488 hasRelatedWork W2049284715 @default.
• W2044438488 hasRelatedWork W2056849036 @default.
• W2044438488 hasRelatedWork W2071871778 @default.
• W2044438488 hasRelatedWork W2094672900 @default.
• W2044438488 hasRelatedWork W2121469406 @default.
• W2044438488 hasRelatedWork W2418646588 @default.
• W2044438488 hasRelatedWork W2426587483 @default.
• W2044438488 isParatext "false" @default.
• W2044438488 isRetracted "false" @default.
• W2044438488 magId "2044438488" @default.
• W2044438488 workType "article" @default.