Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044440434> ?p ?o ?g. }
- W2044440434 endingPage "711" @default.
- W2044440434 startingPage "706" @default.
- W2044440434 abstract "The presence of nitric oxide (NO) in the nose is well documented; however, the role of this molecule in nasal physiology is still poorly understood. Our laboratory has previously demonstrated that NO is a mediator of the immediate secretory response to an intranasal histamine challenge in a rat model of nasal allergy. Histamine challenge, however, does not elicit a late-phase response (LPR). To study the role of NO in the LPR, we developed a model of nasal allergy in which brown Norway rats are actively sensitized to the allergen ovalbumin and later challenged intranasally with either phosphatebuffered saline solution (vehicle), ovalbumin in vehicle, or ovalbumin and the NO synthase inhibitor N-nitro-L-arginine methyl ester. In each experiment, nasal lavage samples were collected 30, 120, 240, and 360 minutes after challenge. Lavage samples were analyzed for albumin content by ELISA, inflammatory cell concentration with a hemocytometer, and evidence of inflammation by light microscopy. Blocking NO synthesis with N-nitro-L-arginine methyl ester significantly inhibited both albumin exudation and inflammatory cell influx into the nasal cavity during the LPR. These data suggest that NO plays a role in the LPR of nasal allergy." @default.
- W2044440434 created "2016-06-24" @default.
- W2044440434 creator A5008421951 @default.
- W2044440434 creator A5009733197 @default.
- W2044440434 creator A5019481761 @default.
- W2044440434 creator A5035852198 @default.
- W2044440434 creator A5050041671 @default.
- W2044440434 creator A5054301416 @default.
- W2044440434 creator A5070230961 @default.
- W2044440434 date "2000-05-01" @default.
- W2044440434 modified "2023-09-27" @default.
- W2044440434 title "Nitric oxide is a mediator of the late‐phase response in an animal model of nasal allergy" @default.
- W2044440434 cites W1968879003 @default.
- W2044440434 cites W1979317956 @default.
- W2044440434 cites W1987386803 @default.
- W2044440434 cites W1990413493 @default.
- W2044440434 cites W1995906883 @default.
- W2044440434 cites W2015523562 @default.
- W2044440434 cites W2019785722 @default.
- W2044440434 cites W2023862497 @default.
- W2044440434 cites W2027874674 @default.
- W2044440434 cites W2030572320 @default.
- W2044440434 cites W2036492535 @default.
- W2044440434 cites W2047450593 @default.
- W2044440434 cites W2048020333 @default.
- W2044440434 cites W2049980621 @default.
- W2044440434 cites W2051603017 @default.
- W2044440434 cites W2053758653 @default.
- W2044440434 cites W2059357525 @default.
- W2044440434 cites W2078259729 @default.
- W2044440434 cites W2126340603 @default.
- W2044440434 cites W2131868847 @default.
- W2044440434 cites W2143570029 @default.
- W2044440434 cites W2154920085 @default.
- W2044440434 cites W2155427063 @default.
- W2044440434 cites W2161633589 @default.
- W2044440434 cites W2170413821 @default.
- W2044440434 cites W2404171958 @default.
- W2044440434 doi "https://doi.org/10.1067/mhn.2000.104015" @default.
- W2044440434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10793351" @default.
- W2044440434 hasPublicationYear "2000" @default.
- W2044440434 type Work @default.
- W2044440434 sameAs 2044440434 @default.
- W2044440434 citedByCount "3" @default.
- W2044440434 crossrefType "journal-article" @default.
- W2044440434 hasAuthorship W2044440434A5008421951 @default.
- W2044440434 hasAuthorship W2044440434A5009733197 @default.
- W2044440434 hasAuthorship W2044440434A5019481761 @default.
- W2044440434 hasAuthorship W2044440434A5035852198 @default.
- W2044440434 hasAuthorship W2044440434A5050041671 @default.
- W2044440434 hasAuthorship W2044440434A5054301416 @default.
- W2044440434 hasAuthorship W2044440434A5070230961 @default.
- W2044440434 hasConcept C1122143 @default.
- W2044440434 hasConcept C134018914 @default.
- W2044440434 hasConcept C141071460 @default.
- W2044440434 hasConcept C185592680 @default.
- W2044440434 hasConcept C203014093 @default.
- W2044440434 hasConcept C207480886 @default.
- W2044440434 hasConcept C2107291 @default.
- W2044440434 hasConcept C2776125364 @default.
- W2044440434 hasConcept C2776914184 @default.
- W2044440434 hasConcept C2776946954 @default.
- W2044440434 hasConcept C2777397205 @default.
- W2044440434 hasConcept C2777622882 @default.
- W2044440434 hasConcept C2778801703 @default.
- W2044440434 hasConcept C2779675166 @default.
- W2044440434 hasConcept C2909814679 @default.
- W2044440434 hasConcept C519581460 @default.
- W2044440434 hasConcept C59377437 @default.
- W2044440434 hasConcept C71924100 @default.
- W2044440434 hasConcept C85663871 @default.
- W2044440434 hasConcept C8891405 @default.
- W2044440434 hasConcept C98274493 @default.
- W2044440434 hasConceptScore W2044440434C1122143 @default.
- W2044440434 hasConceptScore W2044440434C134018914 @default.
- W2044440434 hasConceptScore W2044440434C141071460 @default.
- W2044440434 hasConceptScore W2044440434C185592680 @default.
- W2044440434 hasConceptScore W2044440434C203014093 @default.
- W2044440434 hasConceptScore W2044440434C207480886 @default.
- W2044440434 hasConceptScore W2044440434C2107291 @default.
- W2044440434 hasConceptScore W2044440434C2776125364 @default.
- W2044440434 hasConceptScore W2044440434C2776914184 @default.
- W2044440434 hasConceptScore W2044440434C2776946954 @default.
- W2044440434 hasConceptScore W2044440434C2777397205 @default.
- W2044440434 hasConceptScore W2044440434C2777622882 @default.
- W2044440434 hasConceptScore W2044440434C2778801703 @default.
- W2044440434 hasConceptScore W2044440434C2779675166 @default.
- W2044440434 hasConceptScore W2044440434C2909814679 @default.
- W2044440434 hasConceptScore W2044440434C519581460 @default.
- W2044440434 hasConceptScore W2044440434C59377437 @default.
- W2044440434 hasConceptScore W2044440434C71924100 @default.
- W2044440434 hasConceptScore W2044440434C85663871 @default.
- W2044440434 hasConceptScore W2044440434C8891405 @default.
- W2044440434 hasConceptScore W2044440434C98274493 @default.
- W2044440434 hasIssue "5" @default.
- W2044440434 hasLocation W20444404341 @default.
- W2044440434 hasOpenAccess W2044440434 @default.
- W2044440434 hasPrimaryLocation W20444404341 @default.