FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044447130> ?p ?o ?g. }

• W2044447130 endingPage "1468" @default.
• W2044447130 startingPage "1452" @default.
• W2044447130 abstract "Fusion of the viral and host cell membranes is a necessary first step for infection by enveloped viruses and is mediated by the envelope glycoprotein. The transmembrane subunits from the structurally defined class I glycoproteins adopt an α-helical trimer-of-hairpins conformation during the fusion pathway. Here, we present our studies on the envelope glycoprotein transmembrane subunit, GP2, of the CAS virus (CASV). CASV was recently identified from annulated tree boas (Corallus annulatus) with inclusion body disease and is implicated in the disease etiology. We have generated and characterized two protein constructs consisting of the predicted CASV GP2 core domain. The crystal structure of the CASV GP2 post-fusion conformation indicates a trimeric α-helical bundle that is highly similar to those of Ebola virus and Marburg virus GP2 despite CASV genome homology to arenaviruses. Denaturation studies demonstrate that the stability of CASV GP2 is pH dependent with higher stability at lower pH; we propose that this behavior is due to a network of interactions among acidic residues that would destabilize the α-helical bundle under conditions where the side chains are deprotonated. The pH-dependent stability of the post-fusion structure has been observed in Ebola virus and Marburg virus GP2, as well as other viruses that enter via the endosome. Infection experiments with CASV and the related Golden Gate virus support a mechanism of entry that requires endosomal acidification. Our results suggest that, despite being primarily arenavirus like, the transmembrane subunit of CASV is extremely similar to the filoviruses." @default.
• W2044447130 created "2016-06-24" @default.
• W2044447130 creator A5006013523 @default.
• W2044447130 creator A5012887043 @default.
• W2044447130 creator A5030038763 @default.
• W2044447130 creator A5039121999 @default.
• W2044447130 creator A5039824565 @default.
• W2044447130 creator A5056939900 @default.
• W2044447130 creator A5061136260 @default.
• W2044447130 creator A5076543650 @default.
• W2044447130 creator A5078404116 @default.
• W2044447130 creator A5086914983 @default.
• W2044447130 creator A5089260834 @default.
• W2044447130 date "2014-04-01" @default.
• W2044447130 modified "2023-10-17" @default.
• W2044447130 title "Structural Characterization of the Glycoprotein GP2 Core Domain from the CAS Virus, a Novel Arenavirus-Like Species" @default.
• W2044447130 cites W1539796472 @default.
• W2044447130 cites W1544234519 @default.
• W2044447130 cites W1760776415 @default.
• W2044447130 cites W1797010585 @default.
• W2044447130 cites W1965136586 @default.
• W2044447130 cites W1968280887 @default.
• W2044447130 cites W1971267806 @default.
• W2044447130 cites W1972788506 @default.
• W2044447130 cites W1993999867 @default.
• W2044447130 cites W1997511430 @default.
• W2044447130 cites W1997831273 @default.
• W2044447130 cites W2001641653 @default.
• W2044447130 cites W2016129416 @default.
• W2044447130 cites W2016765195 @default.
• W2044447130 cites W2018737653 @default.
• W2044447130 cites W2022339063 @default.
• W2044447130 cites W2031721139 @default.
• W2044447130 cites W2038390244 @default.
• W2044447130 cites W2043829974 @default.
• W2044447130 cites W2049106045 @default.
• W2044447130 cites W2052188940 @default.
• W2044447130 cites W2055806138 @default.
• W2044447130 cites W2059205813 @default.
• W2044447130 cites W2060533439 @default.
• W2044447130 cites W2068231898 @default.
• W2044447130 cites W2075818175 @default.
• W2044447130 cites W2081524511 @default.
• W2044447130 cites W2093661319 @default.
• W2044447130 cites W2096025413 @default.
• W2044447130 cites W2102286438 @default.
• W2044447130 cites W2102532874 @default.
• W2044447130 cites W2110951885 @default.
• W2044447130 cites W2116943112 @default.
• W2044447130 cites W2118364979 @default.
• W2044447130 cites W2121293808 @default.
• W2044447130 cites W2127440699 @default.
• W2044447130 cites W2143312809 @default.
• W2044447130 cites W2144081223 @default.
• W2044447130 cites W2144998676 @default.
• W2044447130 cites W2147025823 @default.
• W2044447130 cites W2149707830 @default.
• W2044447130 cites W2153074293 @default.
• W2044447130 cites W2154714625 @default.
• W2044447130 cites W2154957091 @default.
• W2044447130 cites W2163729356 @default.
• W2044447130 cites W2165499430 @default.
• W2044447130 cites W2167391272 @default.
• W2044447130 cites W2168464835 @default.
• W2044447130 cites W2169112650 @default.
• W2044447130 cites W2409859699 @default.
• W2044447130 doi "https://doi.org/10.1016/j.jmb.2013.12.009" @default.
• W2044447130 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3951589" @default.
• W2044447130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24333483" @default.
• W2044447130 hasPublicationYear "2014" @default.
• W2044447130 type Work @default.
• W2044447130 sameAs 2044447130 @default.
• W2044447130 citedByCount "24" @default.
• W2044447130 countsByYear W20444471302014 @default.
• W2044447130 countsByYear W20444471302015 @default.
• W2044447130 countsByYear W20444471302016 @default.
• W2044447130 countsByYear W20444471302017 @default.
• W2044447130 countsByYear W20444471302018 @default.
• W2044447130 countsByYear W20444471302019 @default.
• W2044447130 countsByYear W20444471302020 @default.
• W2044447130 countsByYear W20444471302021 @default.
• W2044447130 countsByYear W20444471302022 @default.
• W2044447130 crossrefType "journal-article" @default.
• W2044447130 hasAuthorship W2044447130A5006013523 @default.
• W2044447130 hasAuthorship W2044447130A5012887043 @default.
• W2044447130 hasAuthorship W2044447130A5030038763 @default.
• W2044447130 hasAuthorship W2044447130A5039121999 @default.
• W2044447130 hasAuthorship W2044447130A5039824565 @default.
• W2044447130 hasAuthorship W2044447130A5056939900 @default.
• W2044447130 hasAuthorship W2044447130A5061136260 @default.
• W2044447130 hasAuthorship W2044447130A5076543650 @default.
• W2044447130 hasAuthorship W2044447130A5078404116 @default.
• W2044447130 hasAuthorship W2044447130A5086914983 @default.
• W2044447130 hasAuthorship W2044447130A5089260834 @default.
• W2044447130 hasBestOaLocation W20444471301 @default.
• W2044447130 hasConcept C102747710 @default.
• W2044447130 hasConcept C103038307 @default.
• W2044447130 hasConcept C104292427 @default.

• next