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- W2044460557 abstract "A series of 5′-O- acyl derivatives (2a-e) of 5-ethyl-2′-deoxyuridine (EDU, EtUdR) were prepared by direct acylation of the parent nucleoside 1 in pyridine/N,N-dimethylformamide (DMF). These compounds, designed as prodrugs of 1, offer a wider range of solubilities and lipophilicities than 1. The antiviral activities (against herpes simplex virus types 1 and 2) of all compounds were determined in primary rabbit kidney (PRK) cell cultures. Prodrugs von 5-Ethyl-2′-desoxyuridin, 1. Mitt.: Synthese und antivirale Aktivität einiger 5′-0-Eine Serie von 5′-0-(Acy1)-Derivaten Eine Serie von 5′-0-(Acy1)-Derivaten (2e-e) von 5-Ethyl-2′-desoxyuridin (EDU, EtUdR) wurde durch direkte Acylierung des Ausgangsnukleosides 1 in Pyridin/N,N-Dimethylformamid (DMF) hergestellt. Diese Substanzen, Prodrugs von 1, bieten ein größeres Spektrum an Löslichkeit und Lipophilie gegenüber 1. Die antivirale Aktivität (gegen Herpes Simplex Virus Typ 1 und 2) aller Verbindungen wurde in primären Kaninchennieren-Zellkulturen bestimmt." @default.
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- W2044460557 date "1984-01-01" @default.
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- W2044460557 title "Syntheses and Antiviral Activities of Some 5′-O-Acyl Derivatives" @default.
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- W2044460557 doi "https://doi.org/10.1002/ardp.19843171011" @default.
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