Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044460821> ?p ?o ?g. }
- W2044460821 endingPage "2209" @default.
- W2044460821 startingPage "2200" @default.
- W2044460821 abstract "Glioblastoma is a disease with poor survival rates after diagnosis. Treatment of the disease involves debulking of the tumor, which is limited by the degree of invasiveness of the disease. Therefore, a treatment to halt the invasion of glioma is desirable for clinical implementation. There have been several candidate compounds targeting specific aspects of invasion, including cell adhesions, matrix degradation, and cytoskeletal rearrangement, but they have failed clinically for a variety of reasons. New targets against glioma invasion include upstream mediators of these classical targets in an effort to better inhibit invasion with more specificity for cancer. Included in these treatments is a new class of compounds inhibiting the generation of reactive oxygen species by targeting the NADPH oxidases. These compounds stand to inhibit multiple pathways, including nuclear factor kappa B and Akt. By conducting a screen of compounds thought to inhibit these pathways, a new compound to halt invasion was found that may have a beneficial effect against glioma, based on recent publications. Further, there are still limitations to the treatment of glioblastoma regardless of the discovery of new targets and compounds that should be addressed to better the therapies against this deadly cancer." @default.
- W2044460821 created "2016-06-24" @default.
- W2044460821 creator A5004887935 @default.
- W2044460821 creator A5007185946 @default.
- W2044460821 creator A5039047336 @default.
- W2044460821 creator A5040980144 @default.
- W2044460821 creator A5046943484 @default.
- W2044460821 creator A5049365455 @default.
- W2044460821 date "2013-07-15" @default.
- W2044460821 modified "2023-10-01" @default.
- W2044460821 title "Identifying new small molecule anti-invasive compounds for glioma treatment" @default.
- W2044460821 cites W1482210527 @default.
- W2044460821 cites W1509500531 @default.
- W2044460821 cites W1519477593 @default.
- W2044460821 cites W1536836107 @default.
- W2044460821 cites W1548997088 @default.
- W2044460821 cites W1587753177 @default.
- W2044460821 cites W1599033491 @default.
- W2044460821 cites W1861502977 @default.
- W2044460821 cites W1886614039 @default.
- W2044460821 cites W1963825970 @default.
- W2044460821 cites W1969292950 @default.
- W2044460821 cites W1972489993 @default.
- W2044460821 cites W1975992482 @default.
- W2044460821 cites W1976578289 @default.
- W2044460821 cites W1977127004 @default.
- W2044460821 cites W1979040428 @default.
- W2044460821 cites W1982785575 @default.
- W2044460821 cites W1984483611 @default.
- W2044460821 cites W1985101080 @default.
- W2044460821 cites W1987452783 @default.
- W2044460821 cites W1989448848 @default.
- W2044460821 cites W1989786060 @default.
- W2044460821 cites W1992859930 @default.
- W2044460821 cites W1996387393 @default.
- W2044460821 cites W1998722839 @default.
- W2044460821 cites W1999797961 @default.
- W2044460821 cites W2003736915 @default.
- W2044460821 cites W2009058800 @default.
- W2044460821 cites W2017331741 @default.
- W2044460821 cites W2017475717 @default.
- W2044460821 cites W2027098220 @default.
- W2044460821 cites W2027125377 @default.
- W2044460821 cites W2027260180 @default.
- W2044460821 cites W2033093399 @default.
- W2044460821 cites W2039564026 @default.
- W2044460821 cites W2045226237 @default.
- W2044460821 cites W2046056065 @default.
- W2044460821 cites W2054184538 @default.
- W2044460821 cites W2054889208 @default.
- W2044460821 cites W2056918364 @default.
- W2044460821 cites W2058263436 @default.
- W2044460821 cites W2059441188 @default.
- W2044460821 cites W2061593819 @default.
- W2044460821 cites W2062741733 @default.
- W2044460821 cites W2064308026 @default.
- W2044460821 cites W2066719519 @default.
- W2044460821 cites W2073234761 @default.
- W2044460821 cites W2074812494 @default.
- W2044460821 cites W2079061893 @default.
- W2044460821 cites W2087677309 @default.
- W2044460821 cites W2091846255 @default.
- W2044460821 cites W2093118233 @default.
- W2044460821 cites W2093227016 @default.
- W2044460821 cites W2096287682 @default.
- W2044460821 cites W2099854686 @default.
- W2044460821 cites W2100757571 @default.
- W2044460821 cites W2100959692 @default.
- W2044460821 cites W2104105936 @default.
- W2044460821 cites W2106265598 @default.
- W2044460821 cites W2112719371 @default.
- W2044460821 cites W2112976991 @default.
- W2044460821 cites W2113676592 @default.
- W2044460821 cites W2115516828 @default.
- W2044460821 cites W2119742386 @default.
- W2044460821 cites W2120427205 @default.
- W2044460821 cites W2126116174 @default.
- W2044460821 cites W2129269004 @default.
- W2044460821 cites W2132506474 @default.
- W2044460821 cites W2135823227 @default.
- W2044460821 cites W2136884736 @default.
- W2044460821 cites W2140088548 @default.
- W2044460821 cites W2140102023 @default.
- W2044460821 cites W2142839601 @default.
- W2044460821 cites W2144273675 @default.
- W2044460821 cites W2144670533 @default.
- W2044460821 cites W2145781637 @default.
- W2044460821 cites W2146267383 @default.
- W2044460821 cites W2146881541 @default.
- W2044460821 cites W2147182047 @default.
- W2044460821 cites W2148549004 @default.
- W2044460821 cites W2150032784 @default.
- W2044460821 cites W2154154147 @default.
- W2044460821 cites W2158769524 @default.
- W2044460821 cites W2161336519 @default.
- W2044460821 cites W2162989569 @default.
- W2044460821 cites W2166676058 @default.
- W2044460821 cites W2168267246 @default.