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- W2044461115 abstract "The effect of human recombinant platelet‐derived growth factor (PDGF) isoforms, (r)PDGF‐AA, PDGF‐AB and PDGF‐BB, on contractility of rat aortic rings as well as on intercellular free Ca 2+ ([Ca 2+ ] i ), intracellular pH i (pH i ) and thromboxane A 2 (TXA 2 ) formation in cultured vascular smooth muscle cells (VSMC) was examined. PDGF‐BB behaved similar to PDGF‐AB and both have features characteristic of conventional vasocontrictor‐agonists that directly increase [Ca 2+ ] i , activate the Na + /H + exchanger, stimulate the TXA 2 formation, and induced contraction in VSMC whereas PDGF‐AA induced contraction without increasing of [Ca 2+ ] i , pH i , and TXA 2 formation." @default.
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- W2044461115 title "The platelet-derived growth factor isomers, PDGF-AA, PDGF-AB and PDGF-BB, induce contraction of vascular smooth muscle cells by different intracellular mechanisms" @default.
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- W2044461115 doi "https://doi.org/10.1016/0014-5793(90)81447-v" @default.
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