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• W2044468716 abstract "No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Apr 2000CORRELATION BETWEEN THE STRUCTURE AND FUNCTION OF THE RABBIT URINARY BLADDER FOLLOWING PARTIAL OUTLET OBSTRUCTION JOHN A. GOSLING, L.S. KUNG, JOHN S. DIXON, PATRICK HORAN, CATHERINE WHITBECK, and ROBERT M. LEVIN JOHN A. GOSLINGJOHN A. GOSLING More articles by this author , L.S. KUNGL.S. KUNG More articles by this author , JOHN S. DIXONJOHN S. DIXON More articles by this author , PATRICK HORANPATRICK HORAN More articles by this author , CATHERINE WHITBECKCATHERINE WHITBECK More articles by this author , and ROBERT M. LEVINROBERT M. LEVIN More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)67776-2AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: To understand the relationship between contractile and structural changes in the obstructed bladder, rabbit bladder was partially obstructed for up to 70 days and alterations in tension response to field stimulation and carbachol were compared with alterations in ultrastructure and innervation of detrusor smooth muscle (SM). The effect of partial outlet obstruction on the physiological responses to field stimulation (FS) (nerve mediated contraction) and carbachol (receptor mediated contraction) were correlated with the structure and innervation of the detrusor smooth muscle (SM) of the same animal during a 70 day period. Materials and Methods: 28 rabbits were subjected to 1 to 70 days of mild partial outlet obstruction. Sham operated rabbits were euthanized at 7, 14, 28, and 70 days post-obstruction. At each time period, isolated strips of bladder body were mounted in individual baths and the contractile response to FS and carbachol determined. Three additional strips from each bladder were fixed for electron microscopy. Results: Bladder mass increased rapidly during the first 7 days after obstruction, was constant for the next 7 days, and then continued to increase gradually. Dysfunction of the contractile response to FS was noted as early as 3 days and progressively increased over the 70-day study period. The decrease in the response to FS increased at a significantly faster rate than the decrease in the contractile response to carbachol. In ultrastructure studies, at 3 and 7 days post-obstruction the majority of SM cells displayed the characteristics of hypertrophy. At 28 days some SM cells displayed loosely packed myofilaments and an irregular distribution of sarcoplasmic dense bodies. At 70 days swollen mitochondria were present in all cell types of the bladder wall. Evidence of axonal degeneration was first observed at 7 days post-obstruction and became more extensive thereafter. No evidence of mitotic figures, nerve growth cones or regenerating SM cells was observed. Conclusions: Prolonged partial bladder outflow obstruction is accompanied by a progressive decrease in contractility of SM. The present study describes the structural damage that occurs in the bladder wall in response to partial outlet obstruction and correlates these observations with the contractile dysfunction with which it is associated. Furthermore, mitochondrial damage in vessels and fibroblasts is suggestive of bladder wall ischemia. References 1 : Benign prostatic hyperplasia. In: . Chicago: Year Book Medical Publishers1987: 1062. Google Scholar 2 : Effect of bladder outlet obstruction on the morphology, physiology, and pharmacology of the bladder. Prostate1990; 3: 9. 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Mol Cell Biochem (In press) Google Scholar From the Division of Anatomy, Stanford University, Stanford, California, the Department of Anatomy, Chinese University of Hong Kong, Hong Kong, People’s Republic of China, and the Stratton Veteran’s Affairs Medical Center and Albany College of Pharmacy, Albany, New York© 2000 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byGriebling T (2019) Re: Clinical Epidemiology: Detrusor Voiding Contraction Maximum Power, Related to AgeingJournal of Urology, VOL. 202, NO. 3, (440-440), Online publication date: 1-Sep-2019.Crescenze I, Abraham N, Li J, Goldman H and Vasavada S (2016) Urgency Incontinence before and after Revision of a Synthetic Mid Urethral SlingJournal of Urology, VOL. 196, NO. 2, (478-483), Online publication date: 1-Aug-2016.Hashitani H, Takano H, Fujita K, Mitsui R and Suzuki H (2011) Functional Properties of Suburothelial Microvessels in the Rat BladderJournal of Urology, VOL. 185, NO. 6, (2382-2391), Online publication date: 1-Jun-2011.Cannon G, Mullins C, Lucia M, Hayward S, Lin V, Liu B, Slawin K, Rubin M and Getzenberg R (2018) A Preliminary Study of JM-27: A Serum Marker That Can Specifically Identify Men With Symptomatic Benign Prostatic HyperplasiaJournal of Urology, VOL. 177, NO. 2, (610-614), Online publication date: 1-Feb-2007.Stanton M, Austin J, Delaney D, Gosfield A, Marx J, Zderic S, Chacko S and Moreland R (2018) Partial Bladder Outlet Obstruction Selectively Abolishes Protein Kinase C Induced Contraction of Rabbit Detrusor Smooth MuscleJournal of Urology, VOL. 176, NO. 6, (2716-2721), Online publication date: 1-Dec-2006.Kawano K, Masuda H, Yano M, Kihara K, Sugimoto A and Azuma H (2018) Altered Nitric Oxide Synthase, Arginase and Ornithine Decarboxylase Activities, and Polyamine Synthesis in Response to Ischemia of the Rabbit DetrusorJournal of Urology, VOL. 176, NO. 1, (387-393), Online publication date: 1-Jul-2006.LEVIN R and HUDSON A (2018) THE MOLECULAR GENETIC BASIS OF MITOCHONDRIAL MALFUNCTION IN BLADDER TISSUE FOLLOWING OUTLET OBSTRUCTIONJournal of Urology, VOL. 172, NO. 2, (438-447), Online publication date: 1-Aug-2004.LEVIN R, HASS M, BELLAMY F, HORAN P, WHITBECK K, CHOW P, KUNG L and GOSLING J (2018) Effect of Oral Tadenan Treatment on Rabbit Bladder Structure and Function After Partial Outlet ObstructionJournal of Urology, VOL. 167, NO. 5, (2253-2259), Online publication date: 1-May-2002.CALVERT R, THOMPSON C, KHAN M, MIKHAILIDIS D, MORGAN R and BURNSTOCK G (2018) ALTERATIONS IN CHOLINERGIC AND PURINERGIC SIGNALING IN A MODEL OF THE OBSTRUCTED BLADDERJournal of Urology, VOL. 166, NO. 4, (1530-1533), Online publication date: 1-Oct-2001.PAREKH M, LOBEL R, O’CONNOR L, LEGGETT R and LEVIN R (2018) PROTECTIVE EFFECT OF VITAMIN E ON THE RESPONSE OF THE RABBIT BLADDER TO PARTIAL OUTLET OBSTRUCTIONJournal of Urology, VOL. 166, NO. 1, (341-346), Online publication date: 1-Jul-2001. Volume 163Issue 4April 2000Page: 1349-1356 Advertisement Copyright & Permissions© 2000 by American Urological Association, Inc.Keywordssarcoplasmic reticulumobstructionmitochondriabladdernerveMetricsAuthor Information JOHN A. GOSLING More articles by this author L.S. KUNG More articles by this author JOHN S. DIXON More articles by this author PATRICK HORAN More articles by this author CATHERINE WHITBECK More articles by this author ROBERT M. LEVIN More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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