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• W2044469997 abstract "MiR-145 is reported to be significantly down-regulated in ovarian cancer. This study was aimed at elucidating the roles of miR-145 in regulating the biological behavior of epithelial ovarian cancer (EOC) cells. In this report, we find out that up-regulation of miR-145 in OVCAR-3 and SKOV-3 cells inhibit cell proliferation and promote cell apoptosis. We show that miR-145 directly target the c-Myc 3′-UTR. Moreover, ectopic expression of c-Myc reduces the inhibition of cell proliferation caused by miR-145 transfection. Cell cycle assay showed that up-regulation of miR-145 reduces S phase population, and restoration of c-Myc can rescue this reduction. These findings indicate that miR-145 inhibits cell proliferation and promotes cell apoptosis by targeting c-Myc 3′-UTR. Therefore, the result indicated that miR-145 could be used as a potential therapeutic target in ovarian cancer." @default.
• W2044469997 created "2016-06-24" @default.
• W2044469997 creator A5008306236 @default.
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• W2044469997 date "2014-04-01" @default.
• W2044469997 modified "2023-09-25" @default.
• W2044469997 title "MicroRNA-145 Function as a Cell Growth Repressor by Directly Targeting c-Myc in Human Ovarian Cancer" @default.
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• W2044469997 doi "https://doi.org/10.7785/tcrt.2012.500367" @default.
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