FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044481780> ?p ?o ?g. }

• W2044481780 endingPage "28" @default.
• W2044481780 startingPage "19" @default.
• W2044481780 abstract "SUMMARY Aim To evaluate the long‐term effect of changes in body composition induced by weight loss on insulin sensitivity (S I ), non‐insulin mediated glucose disposal, glucose effectiveness (S G ) and β‐cell function. Design Glucose metabolism was evaluated before and after participation in a two‐year weight loss trial of Orlistat vs. placebo, combined with an energy and fat restricted diet. Subjects Twelve obese patients (11 women, 1 man), age 45.8 ± 10.5 years, body weight (BW) 99.7 ± 13.3 kg, BMI 35.3 ± 2.8 kg/m 2 . Measurements At inclusion and 2 years later an oral glucose tolerance test (OGTT) and a frequently sampled intravenous glucose tolerance test (FSIGT) were performed. Body composition was estimated by a dual‐energy X‐ray absorptiometry (DXA) whole body scanning. Results The patients obtained varying changes in BW ranging from a weight loss of 17.8 kg to a weight gain of 6.0 kg. Corresponding changes in fat mass (FM) varied from a 40% reduction to a 19% increase. A significant decrease in both fasting (p = 0.038) and 2 h (p = 0.047) blood glucose at OGTT was found. The improvement in insulin sensitivity (S I ) estimated by means of Bergmans Minimal Model, was significantly and linearly correlated to change in total FM ( r = − 0.83, p = 0.0026). A multiple regression analysis showed that changes in truncal FM was the strongest predictor of change in S I explaining 67% of the variation. First phase insulin response (AIRg) remained unchanged whereas insulin disposition index increased significantly (p = 0.044). At inclusion five patients had impaired glucose tolerance of which four, who lost weight, were normalized at the retest 2 years later. Conclusion In obese subjects long‐term minimal or moderate changes in weight were found to be linearly associated with changes in insulin sensitivity. In obese subjects with impaired glucose tolerance even a minor weight loss was able to normalize glucose tolerance." @default.
• W2044481780 created "2016-06-24" @default.
• W2044481780 creator A5038061490 @default.
• W2044481780 creator A5044830255 @default.
• W2044481780 creator A5051323783 @default.
• W2044481780 creator A5061770603 @default.
• W2044481780 creator A5062239390 @default.
• W2044481780 creator A5065526075 @default.
• W2044481780 creator A5073820582 @default.
• W2044481780 date "2002-01-01" @default.
• W2044481780 modified "2023-10-18" @default.
• W2044481780 title "Minor long-term changes in weight have beneficial effects on insulin sensitivity and β-cell function in obese subjects" @default.
• W2044481780 cites W1920052608 @default.
• W2044481780 cites W1964227153 @default.
• W2044481780 cites W1969055884 @default.
• W2044481780 cites W1992527366 @default.
• W2044481780 cites W1998307737 @default.
• W2044481780 cites W1998714276 @default.
• W2044481780 cites W2008699478 @default.
• W2044481780 cites W2013491071 @default.
• W2044481780 cites W2015391533 @default.
• W2044481780 cites W2020914475 @default.
• W2044481780 cites W2029046331 @default.
• W2044481780 cites W2041008935 @default.
• W2044481780 cites W2044964910 @default.
• W2044481780 cites W2046666469 @default.
• W2044481780 cites W2055689111 @default.
• W2044481780 cites W2061309116 @default.
• W2044481780 cites W2075047932 @default.
• W2044481780 cites W2079752464 @default.
• W2044481780 cites W2085194341 @default.
• W2044481780 cites W2105290412 @default.
• W2044481780 cites W2107132553 @default.
• W2044481780 cites W2108146517 @default.
• W2044481780 cites W2110713453 @default.
• W2044481780 cites W2111968328 @default.
• W2044481780 cites W2112834655 @default.
• W2044481780 cites W2127283734 @default.
• W2044481780 cites W2130171861 @default.
• W2044481780 cites W2134860420 @default.
• W2044481780 cites W2136520528 @default.
• W2044481780 cites W2153962063 @default.
• W2044481780 cites W2165047605 @default.
• W2044481780 cites W2166233282 @default.
• W2044481780 cites W2166266400 @default.
• W2044481780 cites W2262457072 @default.
• W2044481780 cites W2317730087 @default.
• W2044481780 cites W2330273698 @default.
• W2044481780 cites W4249562928 @default.
• W2044481780 cites W4250449211 @default.
• W2044481780 doi "https://doi.org/10.1046/j.1463-1326.2002.00161.x" @default.
• W2044481780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11890163" @default.
• W2044481780 hasPublicationYear "2002" @default.
• W2044481780 type Work @default.
• W2044481780 sameAs 2044481780 @default.
• W2044481780 citedByCount "41" @default.
• W2044481780 countsByYear W20444817802013 @default.
• W2044481780 countsByYear W20444817802016 @default.
• W2044481780 countsByYear W20444817802017 @default.
• W2044481780 countsByYear W20444817802022 @default.
• W2044481780 crossrefType "journal-article" @default.
• W2044481780 hasAuthorship W2044481780A5038061490 @default.
• W2044481780 hasAuthorship W2044481780A5044830255 @default.
• W2044481780 hasAuthorship W2044481780A5051323783 @default.
• W2044481780 hasAuthorship W2044481780A5061770603 @default.
• W2044481780 hasAuthorship W2044481780A5062239390 @default.
• W2044481780 hasAuthorship W2044481780A5065526075 @default.
• W2044481780 hasAuthorship W2044481780A5073820582 @default.
• W2044481780 hasConcept C126322002 @default.
• W2044481780 hasConcept C134018914 @default.
• W2044481780 hasConcept C142724271 @default.
• W2044481780 hasConcept C204787440 @default.
• W2044481780 hasConcept C27081682 @default.
• W2044481780 hasConcept C2777180221 @default.
• W2044481780 hasConcept C2777391703 @default.
• W2044481780 hasConcept C2779306644 @default.
• W2044481780 hasConcept C2780833929 @default.
• W2044481780 hasConcept C3017594256 @default.
• W2044481780 hasConcept C3017594758 @default.
• W2044481780 hasConcept C3017894415 @default.
• W2044481780 hasConcept C3020574416 @default.
• W2044481780 hasConcept C511355011 @default.
• W2044481780 hasConcept C544821477 @default.
• W2044481780 hasConcept C555293320 @default.
• W2044481780 hasConcept C71924100 @default.
• W2044481780 hasConceptScore W2044481780C126322002 @default.
• W2044481780 hasConceptScore W2044481780C134018914 @default.
• W2044481780 hasConceptScore W2044481780C142724271 @default.
• W2044481780 hasConceptScore W2044481780C204787440 @default.
• W2044481780 hasConceptScore W2044481780C27081682 @default.
• W2044481780 hasConceptScore W2044481780C2777180221 @default.
• W2044481780 hasConceptScore W2044481780C2777391703 @default.
• W2044481780 hasConceptScore W2044481780C2779306644 @default.
• W2044481780 hasConceptScore W2044481780C2780833929 @default.
• W2044481780 hasConceptScore W2044481780C3017594256 @default.
• W2044481780 hasConceptScore W2044481780C3017594758 @default.
• W2044481780 hasConceptScore W2044481780C3017894415 @default.
• W2044481780 hasConceptScore W2044481780C3020574416 @default.

• next