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- W2044482083 abstract "Acute dissection and rupture of aortic aneurysms comprise for 1–2% of all deaths in industrialized countries. Dilation of the aorta is caused by a multitude of mechanisms including inherited connective tissue disorders such as Marfan syndrome (MFS). MFS is one of the most common inherited connective tissue disorders affecting 1 in 5000 individuals. Although the phenotype of MFS can be quite variable, aneurysmal dilation of the aortic root and consecutive acute aortic dissection is the leading cause of death in this patient population. Over the past years it has been shown that a comprehensive understanding of this disorder provides greater understanding of vascular wall biology and identifies pathways relevant to aortic aneurysms and dissection in general. The current review discusses the surgical management of patients with MFS with a special emphasis on indications for surgery in this complex group of patients." @default.
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- W2044482083 date "2011-07-01" @default.
- W2044482083 modified "2023-10-17" @default.
- W2044482083 title "Cardiovascular surgery in Marfan syndrome: implications of new molecular concepts in thoracic aortic disease" @default.
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- W2044482083 doi "https://doi.org/10.2217/fca.11.37" @default.
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