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• W2044483947 abstract "A series of new 5-hydroxylquinolone-3-carboxylic acids (HQCAs) with various aryl or benzyl substituents on N-1 position were synthesized and evaluated for their anti-HIV activity in C8166 cell culture. Most of the target compounds displayed activity against wide-type HIV-1 in the low micromolar range in infected C8166 cells. The most active compound 5 g exhibited activity against wild-type HIV-1 and HIV-1 mutant virus A17 with an EC(50) value of 3.17 and 17.88 μM, respectively. The biological results and the docking study revealed that the substitution pattern on N-1 position of the quinolone core might contribute to physicochemical properties of HQCAs and resulted in great influence on their antiviral potency." @default.
• W2044483947 created "2016-06-24" @default.
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• W2044483947 date "2011-09-01" @default.
• W2044483947 modified "2023-09-23" @default.
• W2044483947 title "Synthesis and biological evaluation of HQCAs with aryl or benzyl substituents on N-1 position as potential HIV-1 integrase inhibitors" @default.
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• W2044483947 doi "https://doi.org/10.1016/j.bmc.2011.07.037" @default.
• W2044483947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21862337" @default.
• W2044483947 hasPublicationYear "2011" @default.
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