FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2044486698> ?p ?o ?g. }

• W2044486698 endingPage "865" @default.
• W2044486698 startingPage "859" @default.
• W2044486698 abstract "La thérapie cellulaire pour le traitement de l’incontinence urinaire est une technique prometteuse. Notre objectif principal était d’établir la tolérance de la technique d’injection intrasphinctérienne de cellules musculaires autologues chez les patients atteints d’incontinence urinaire d’effort (IUE) après prostatectomie totale (PT). Les objectifs secondaires portaient sur l’efficacité et l’évaluation des complications. Une étude ouverte, prospective, dans un centre a été menée chez 12 patients ayant une IUE après PT. Les patients ont eu une injection de cellules musculaires autologues, produites à partir d’une biopsie de muscle deltoïde. Le critère principal était la valeur du débit maximum (Qmax) à trois mois comparé à sa valeur de base. Les critères secondaires étaient les évènements indésirables, et les paramètres évaluant l’efficacité (symptômes, qualité de vie, calendrier mictionnel, pad-test, et profil de pression uréthral) à un, deux, trois, six et 12 mois. Aucune complication immédiate ni aucune variation significative du Qmax n’a été mise en évidence. Les seuls effets secondaires recensés ont été trois cas d’infection urinaire traités par antibiotiques. Les résultats à un an sur l’efficacité étaient hétérogènes, avec réduction des épisodes de fuites chez quatre patients, une augmentation de la pression de clôture chez un patient et une amélioration du pad-test chez huit patients. Dans notre expérience, le traitement de l’IUE après PT par injection de cellules musculaires autologues était une technique faisable et sûre. Certains patients étaient répondeurs au traitement, mais l’efficacité clinique de cette approche reste à confirmer. Cell therapy for urinary incontinence management has been experienced in animals with encouraging results, but studies in human beings are lacking. Our primary objective was to assess the safety of intrasphincteric injections of autologous muscular cells in patients with postprostatectomy incontinence (PPI). Secondary objectives focused on complications efficacy. We conducted an open, prospective study in a single center on 12 patients presenting PPI. Patients underwent intrasphincteric injections of autologous muscular cells isolated from a biopsy of deltoid muscle. The primary endpoint was the Qmax variation at the three month visit in order to assess potential bladder outlet obstruction. Secondary endpoints assessed side effects and efficacy parameters based on symptoms, quality of life score, voiding diary, pad-test, and urethral pressure profile at one, two, three, six and 12 months after injection. No immediate complication occurred and no significant variation was noted on Qmax. The only side effects possibly product-related were three cases of urinary tract infection treated by antibiotics. An acceptable safety and tolerability of the procedure whatever the injected dose of muscular cells was demonstrated. Results on efficacy after one year were heterogeneous, with 4/12 patients describing reduced urine leakage episodes, 1/12 patient presenting increased maximal closure pressure, and 8/12 patients showing improvement on pad-test. Cell therapy consisting of intrasphincteric injections of autologous muscular cells in patients with PPI was a feasible and safe procedure. The results point out that some subjects may positively respond to this procedure, but clinical efficacy remains to be confirmed." @default.
• W2044486698 created "2016-06-24" @default.
• W2044486698 creator A5001791589 @default.
• W2044486698 creator A5014171179 @default.
• W2044486698 creator A5014396815 @default.
• W2044486698 creator A5022683509 @default.
• W2044486698 creator A5026371407 @default.
• W2044486698 creator A5030868662 @default.
• W2044486698 creator A5038667646 @default.
• W2044486698 creator A5052396092 @default.
• W2044486698 creator A5062852558 @default.
• W2044486698 creator A5071851513 @default.
• W2044486698 date "2011-11-01" @default.
• W2044486698 modified "2023-10-01" @default.
• W2044486698 title "Évaluation prospective du traitement de l’incontinence urinaire post-prostatectomie par injections intrasphinctériennes de cellules musculaires autologues" @default.
• W2044486698 cites W1968339106 @default.
• W2044486698 cites W1977380005 @default.
• W2044486698 cites W1991540624 @default.
• W2044486698 cites W1992525914 @default.
• W2044486698 cites W2016521617 @default.
• W2044486698 cites W2023924108 @default.
• W2044486698 cites W2035963411 @default.
• W2044486698 cites W2037180163 @default.
• W2044486698 cites W2043170136 @default.
• W2044486698 cites W2048252028 @default.
• W2044486698 cites W2060290175 @default.
• W2044486698 cites W2072932951 @default.
• W2044486698 cites W2086532398 @default.
• W2044486698 cites W2100409085 @default.
• W2044486698 cites W2110353497 @default.
• W2044486698 cites W2119277749 @default.
• W2044486698 cites W2123230901 @default.
• W2044486698 cites W2134614924 @default.
• W2044486698 cites W2154772081 @default.
• W2044486698 cites W2168161841 @default.
• W2044486698 doi "https://doi.org/10.1016/j.purol.2011.03.001" @default.
• W2044486698 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22035912" @default.
• W2044486698 hasPublicationYear "2011" @default.
• W2044486698 type Work @default.
• W2044486698 sameAs 2044486698 @default.
• W2044486698 citedByCount "7" @default.
• W2044486698 countsByYear W20444866982012 @default.
• W2044486698 countsByYear W20444866982013 @default.
• W2044486698 countsByYear W20444866982014 @default.
• W2044486698 countsByYear W20444866982015 @default.
• W2044486698 crossrefType "journal-article" @default.
• W2044486698 hasAuthorship W2044486698A5001791589 @default.
• W2044486698 hasAuthorship W2044486698A5014171179 @default.
• W2044486698 hasAuthorship W2044486698A5014396815 @default.
• W2044486698 hasAuthorship W2044486698A5022683509 @default.
• W2044486698 hasAuthorship W2044486698A5026371407 @default.
• W2044486698 hasAuthorship W2044486698A5030868662 @default.
• W2044486698 hasAuthorship W2044486698A5038667646 @default.
• W2044486698 hasAuthorship W2044486698A5052396092 @default.
• W2044486698 hasAuthorship W2044486698A5062852558 @default.
• W2044486698 hasAuthorship W2044486698A5071851513 @default.
• W2044486698 hasConcept C126322002 @default.
• W2044486698 hasConcept C126894567 @default.
• W2044486698 hasConcept C141071460 @default.
• W2044486698 hasConcept C168563851 @default.
• W2044486698 hasConcept C188816634 @default.
• W2044486698 hasConcept C197934379 @default.
• W2044486698 hasConcept C203092338 @default.
• W2044486698 hasConcept C2778375690 @default.
• W2044486698 hasConcept C2778531004 @default.
• W2044486698 hasConcept C29456083 @default.
• W2044486698 hasConcept C71924100 @default.
• W2044486698 hasConcept C77411442 @default.
• W2044486698 hasConcept C81182388 @default.
• W2044486698 hasConceptScore W2044486698C126322002 @default.
• W2044486698 hasConceptScore W2044486698C126894567 @default.
• W2044486698 hasConceptScore W2044486698C141071460 @default.
• W2044486698 hasConceptScore W2044486698C168563851 @default.
• W2044486698 hasConceptScore W2044486698C188816634 @default.
• W2044486698 hasConceptScore W2044486698C197934379 @default.
• W2044486698 hasConceptScore W2044486698C203092338 @default.
• W2044486698 hasConceptScore W2044486698C2778375690 @default.
• W2044486698 hasConceptScore W2044486698C2778531004 @default.
• W2044486698 hasConceptScore W2044486698C29456083 @default.
• W2044486698 hasConceptScore W2044486698C71924100 @default.
• W2044486698 hasConceptScore W2044486698C77411442 @default.
• W2044486698 hasConceptScore W2044486698C81182388 @default.
• W2044486698 hasIssue "12" @default.
• W2044486698 hasLocation W20444866981 @default.
• W2044486698 hasLocation W20444866982 @default.
• W2044486698 hasOpenAccess W2044486698 @default.
• W2044486698 hasPrimaryLocation W20444866981 @default.
• W2044486698 hasRelatedWork W2068543068 @default.
• W2044486698 hasRelatedWork W2071699168 @default.
• W2044486698 hasRelatedWork W2156209231 @default.
• W2044486698 hasRelatedWork W2417961914 @default.
• W2044486698 hasRelatedWork W2474039552 @default.
• W2044486698 hasRelatedWork W2766026571 @default.
• W2044486698 hasRelatedWork W2774765706 @default.
• W2044486698 hasRelatedWork W2945124548 @default.
• W2044486698 hasRelatedWork W3212096909 @default.
• W2044486698 hasRelatedWork W4242832529 @default.
• W2044486698 hasVolume "21" @default.

• next