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• W2044487509 abstract "Context Overproduction of catecholamine induces not only hypertension but also glucose intolerance and hyperlipidemia. However, little is known about its effect on visceral and subcutaneous fat. Objective Our objective was to investigate changes of metabolic factors including visceral and subcutaneous fat areas in patients with pheochromocytoma (Pheo). Design and patients This was a cross-sectional and longitudinal follow-up study of cases collected from Gunma University Hospital between 2002 and 2013. Forty-two patients with Pheo and 23 with non-functioning adrenal adenoma (NFA) were analyzed before and after adrenalectomy. Results Multivariate logistic-regression analysis adjusted by age and gender revealed that glucose intolerance was more common in patients with Pheo than in patients with NFA (21/42, 51% vs. 4/23, 17%, p < 0.05). Abdominal visceral fat area (VFA) and subcutaneous fat area (SFA) were significantly lower in patients with Pheo than in those with NFA (80.2 ± 38.7 vs. 124.3 ± 61.8 cm2, p < 0.05; 114.6 ± 58.9 vs. 164.3 ± 40.3 cm2, p < 0.05, respectively). Significant correlations were observed between fractionated urine noradrenaline level and serum HDL-cholesterol level (r = 0.36, p < 0.05), urine normetanephrine level and tumor size (r = 0.57, p < 0.01), and urine adrenaline level and systolic blood pressure (r = 0.35, p < 0.05) in Pheo. However, there were no significant correlations between adrenaline and noradrenaline levels and other parameters, including serum LDL-cholesterol and triglyceride levels, and HbA1c. Furthermore, both VFA and SFA, body weight, and BMI were significantly increased, and serum HbA1c as well as HDL-cholesterol levels were decreased after adrenalectomy in Pheo. Conclusion These findings suggest for the first time that catecholamines might regulate the serum HDL-cholesterol level and both abdominal visceral and subcutaneous fat mass in men." @default.
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• W2044487509 date "2015-06-01" @default.
• W2044487509 modified "2023-09-28" @default.
• W2044487509 title "Changes in visceral and subcutaneous fat mass in patients with pheochromocytoma" @default.
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• W2044487509 doi "https://doi.org/10.1016/j.metabol.2015.03.004" @default.
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