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• W2044487946 endingPage "2333" @default.
• W2044487946 startingPage "2317" @default.
• W2044487946 abstract "Existing AIDS therapies are out of reach for most HIV-infected people in developing countries and, where available, they are limited by their toxicity and their cost. New anti-HIV agents are needed urgently to combat emerging viral resistance and reduce the side effects associated with currently available drugs. Toward this end, LeapFrog, a de novo drug design program was used to design novel, potent, and selective inhibitors of HIV-1 integrase. The designed compounds were synthesized and tested for in vitro inhibition of HIV-1 integrase. Out of the 25 compounds that were designed, and synthesized, four molecules (compounds 23, 26, 43, and 59) showed moderate to low inhibition of HIV-1 integrase for 3'-processing and 3'-strand transfer activities. Nonetheless, these compounds possess structural features not seen in known HIV-1 integrase inhibitors and thus can serve as excellent leads for further optimization of anti-HIV-1 integrase activity." @default.
• W2044487946 created "2016-06-24" @default.
• W2044487946 creator A5023220693 @default.
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• W2044487946 creator A5050245398 @default.
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• W2044487946 date "2004-05-01" @default.
• W2044487946 modified "2023-10-14" @default.
• W2044487946 title "De novo design and synthesis of HIV-1 integrase inhibitors" @default.
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• W2044487946 doi "https://doi.org/10.1016/j.bmc.2004.02.005" @default.
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