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- W20444889 abstract "This chapter presents an analysis of male pseudohermaphroditism in the rat with regard to anatomic, embryologic, genetic, and physiological considerations. The anomaly is transmitted genetically by female carriers to one-half of their male offspring. In addition, one-half of the female offspring of an affected sibship become carriers. Affected males exhibit, in general, a female phenotype characterized by the presence of a blindly ending vaginal recess and mammary line but lack both Müllerian and Wolffian duct systems. Embryologic studies show normal development of Wolffian and Müllerian duct systems up to day 17 in utero, at which time disintegration of these structures takes place. Hence, a male inductor system seems not to be involved, but rather a maintenance factor without which disintegration of the ductal system results. The lack of androgen sensitivity demonstrated in these animals appears to be a reasonable explanation in light of present information. Spermatogenesis does not progress beyond the primary spermatocyte stage in the testes of the pseudohermaphrodite. The interstitial cells show marked proliferation, an indication of gonadotropin stimulation." @default.
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- W20444889 date "1973-01-01" @default.
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- W20444889 title "Part I. Male Pseudohermaphroditism in the Laboratory Norway Rat" @default.
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- W20444889 doi "https://doi.org/10.1016/b978-0-12-571129-6.50005-1" @default.
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