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• W2044497466 abstract "In Brief Goal: The goal of this study was to evaluate the seroprevalence of human herpesvirus 8 (HHV-8) infection among HIV-infected individuals from Brazil and the associated risk factors. Study: A cross-sectional survey was carried out with 497 HIV/AIDS outpatients attending the local AIDS Reference Center in Santos (southeastern Brazil) between February 1997 and January 1998 had serum samples screened for anti-HHV-8 antibodies. Patients were considered seropositive whenever reactivity was observed in at least 1 of 3 tests (immunofluorescence assays for latent nuclear and lytic antigens and orf65 recombinant antigen enzyme-linked immunosorbent assay). Results: Overall HHV-8 seroprevalence was 13.9% (95% confidence interval [CI], 10.9–17.6). HHV-8 coinfection was significantly more frequent in men (18.7%; 95% CI, 14.1–23.4) than in women (7.8%; 95% CI, 4.2–11.3) (P <0.001). According to the mode of HIV acquisition among males, seroprevalence of HHV-8 infection was significantly higher in men who have sex with men when compared with the other groups (32.4% vs. 10.0%, P <0.001). Multivariate logistic regression revealed HHV-8 infection among men to be independently associated with sexual orientation (adjusted odds ratio [AOR], 5.5 for homosexuals; AOR, 2.8 for bisexuals). No significant risk factor for HHV-8 infection could be demonstrated for HIV-infected women in this cohort, Conclusions: This study provides further evidence that men who have sex with men are at higher risk of HHV-8 infection and shows that the epidemiologic pattern of this infection among HIV/AIDS patients from Santos, Brazil, is similar to that described in other countries with a low incidence of Kaposi’s sarcoma. This cross-sectional study provided further evidence that men who have sex with men are at higher risk of HHV-8 infection." @default.
• W2044497466 created "2016-06-24" @default.
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• W2044497466 date "2005-01-01" @default.
• W2044497466 modified "2023-10-18" @default.
• W2044497466 title "Human Herpesvirus 8 (HHV-8) Infection in HIV/AIDS Patients From Santos, Brazil: Seroprevalence and Associated Factors" @default.
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• W2044497466 doi "https://doi.org/10.1097/01.olq.0000148300.33428.6e" @default.
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