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• W2044501119 abstract "Inflammatory bowel diseases (IBD) and colorectal cancer (CRC) are disorders that originate from immune disturbances. In our study, we evaluated the association between the −251 T/A interleukin (IL)-8 and the −1112 C/T IL-13 polymorphisms, the risk of IBD, and CRC development. Genotypes were determined by PCR-restriction fragment length polymorphism in 191 patients with CRC, 150 subjects with IBD, and 205 healthy controls. We found an association between CRC and the presence of the −251 TA genotype and A allele of the IL-8 gene (odds ratios [ORs] 2.28 and 1.65). A similar relationship was observed between these polymorphic variants and ulcerative colitis (OR 2.05 for the −251 TA genotype and OR 1.47 for the −251 A allele) as well as Crohn's disease (ORs 3.11 and 1.56, respectively). Our research also revealed that the CT and TT genotypes of the IL-13 −1112 C/T polymorphism may be connected with a higher risk of CRC (ORs 2.28 and 1.65). The same genotypes affected the susceptibility of IBD (ORs 2.26 and 3.72). Our data showed that the IL-8 −251 T/A and IL-13 −1112 C/T polymorphisms might be associated with the IBD and CRC occurrence and might be used as predictive factors of these diseases in a Polish population. Two inflammatory-associated diseases of the gastrointestinal track may be associated with polymorphisms of cytokines in this article." @default.
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• W2044501119 date "2012-08-01" @default.
• W2044501119 modified "2023-09-30" @default.
• W2044501119 title "The<i>lL-8</i>and<i>IL-13</i>Gene Polymorphisms in Inflammatory Bowel Disease and Colorectal Cancer" @default.
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• W2044501119 doi "https://doi.org/10.1089/dna.2012.1692" @default.
• W2044501119 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3405451" @default.
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