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• W2044504507 abstract "Abstract Despite their hematopoietic origin, mast cells ( MC s) develop exclusively in tissues, hampering their ample use in research. To circumvent this problem, tissue‐derived MC s are typically first expanded in culture, but the changes MC s may undergo in the novel micromilieu are poorly defined. Here, we monitor skin MC s from a number of donors over time, revealing profound yet non‐synchronized modulations in culture. While tryptase and chymase, the most specific markers, strongly decline, Fc ε RI surface expression, and Fc ε RI ‐mediated histamine release steeply increase (from ≈15.5% to ≈60%), replicated by similar increments in TNF ‐ α secretion. Interestingly, the modulations are independent of cell cycle progression, as they are comparable in the growth and postgrowth phase, implying they primarily result from microenvironmental conditioning. The data highlight a high degree of MC versatility, but also advise that results based on cultured MC s should be viewed with some caution, as they may not accurately reflect their counterparts in situ ." @default.
• W2044504507 created "2016-06-24" @default.
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• W2044504507 date "2014-11-25" @default.
• W2044504507 modified "2023-10-02" @default.
• W2044504507 title "Skin mast cells develop non-synchronized changes in typical lineage characteristics upon culture" @default.
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• W2044504507 doi "https://doi.org/10.1111/exd.12558" @default.
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