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• W2044505893 abstract "To determine whether modulation of T-cell responses by naturally occurring viral variants caused an increase in numbers of Tregs in HCV-infected patients.Human peripheral blood mononuclear cells, having proliferative responses to a wild-type HCV-specific CD4+ T-cell epitope, were used to quantify, via proliferative assays, flow cytometry and class II tetramers, the effects of naturally occurring viral variants arising in the immunodominant epitope.In combination, the wild-type and variant peptides led to enhanced suppression of an anti-HCV T-cell response. The variant had a lower avidity for the wild-type-specific CD4+ T cell. Variant-stimulated CD4+ T cells had increased Foxp3, compared with wild-type-stimulated cells.A stable viral variant from a chronic HCV subject was able to induce Tregs in multiple individuals that responded to the wild-type HCV-specific CD4+ T-cell epitope." @default.
• W2044505893 created "2016-06-24" @default.
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• W2044505893 date "2013-07-01" @default.
• W2044505893 modified "2023-10-14" @default.
• W2044505893 title "CD4+T-cell engagement by both wild-type and variant HCV peptides modulates the conversion of viral clearing helper T cells to Tregs" @default.
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• W2044505893 doi "https://doi.org/10.2217/fvl.13.49" @default.
• W2044505893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3887522" @default.
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• W2044505893 hasPublicationYear "2013" @default.
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