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• W2044506661 startingPage "45" @default.
• W2044506661 abstract "Ectopic expression of ROCK II (Rho kinase II or ROKalpha), an effector of Rho GTPase, induces membrane blebbing and chromatin condensation. ROCK II can induce membrane blebbing in the presence of the caspase inhibitor z-VAD-fmk or in caspase-3-deficient MCF-7 cells, indicating that the activation of caspases is not required. ROCK-II-induced membrane blebbing, however, is reversed by the myosin light chain kinase inhibitor ML-7 or cytochalasin D. In addition, the expression of a constitutively activated form of cofilin (S3A-cofilin) suppresses both membrane blebbing and chromatin condensation in ROCK II expressing cells. These findings suggest that the activation of actin-myosin contractility is responsible for membrane blebbing and chromatin condensation and implicate ROCK II as a potential mediator of the morphological changes associated with apoptosis." @default.
• W2044506661 created "2016-06-24" @default.
• W2044506661 creator A5004897720 @default.
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• W2044506661 date "2002-08-01" @default.
• W2044506661 modified "2023-09-27" @default.
• W2044506661 title "ROCK-II-Induced Membrane Blebbing and Chromatin Condensation Require Actin Cytoskeleton" @default.
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• W2044506661 doi "https://doi.org/10.1006/excr.2002.5565" @default.
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